Contributions of T Cell Signaling for Wound Healing

Abstract It has long been known that T cells participate in wound healing; however, the landscape of the signaling derived from T cells in the process of wound healing is still enigmatic. With the advantages of scRNA-seq, in combination with immunofluorescent imaging, we identified activated T cells...

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Veröffentlicht in:Journal of burn care & research 2024-11, Vol.45 (6), p.1513-1519
Hauptverfasser: Meng, Lingzhang, Tang, Qiang, Zhou, Wei, Wei, Dalong, Zhao, Jingjie, Shen, Jiajia, Yang, Mingyue, He, Siyuan, Huang, Shaoang, Qin, Yujuan, Song, Jian, Luo, Liangping, Tang, Qianli
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Sprache:eng
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Zusammenfassung:Abstract It has long been known that T cells participate in wound healing; however, the landscape of the signaling derived from T cells in the process of wound healing is still enigmatic. With the advantages of scRNA-seq, in combination with immunofluorescent imaging, we identified activated T cells, cytotoxic T cells (CTLs), exhausting T cells, and Tregs existing in the inflammation phase of wound healing. Further analysis revealed each T cell population possess distinguished signals contributed to wound healing, some are critical for improving the wound healing quality. Besides, this study discovered and validated the existence of exhausting T cells among the T cells accumulated in the skin during wound healing, and the molecular mechanism(s) and contribution of exhausting T cells to wound healing deserve extensive studies in the future.
ISSN:1559-047X
1559-0488
1559-0488
DOI:10.1093/jbcr/irae151