Associations of glycemic measures in the normal range with all-cause mortality in the absence of traditional risk factors

The investigation of the association between blood glucose within normal range and all-cause mortality among individuals without traditional risk factors is limited. To determine the associations of 3 glycemic measures (fasting plasma glucose [FPG], hemoglobin A1c [HbA1c], and 2-h glucose) in the normal range with all-cause mortality among individuals without traditional risk factors. Retrospective cohort study. US National Health and Nutrition Examination Survey in 1988-1994 and 1999-2018. Non-pregnant adults who had a measurement of 2-h glucose, FPG, and HbA1c, and absence of traditional risk factors were included. Cox proportional hazard models were performed to examine the associations of normal FPG (n=5793), normal HbA1c (n=8179), and normal 2-h glucose (n=3404) with all-cause mortality. The significant association was found between 2-h glucose within the normal range and all-cause mortality among those without traditional risk factors. Compared to participants with 2-h glucose