De novo domestication in the Solanaceae: advances and challenges

The advent of highly efficient genome editing (GE) tools, coupled with high-throughput genome sequencing, has paved the way for the accelerated domestication of crop wild relatives. New crops could thus be rapidly created that are well adapted to cope with drought, flooding, soil salinity, or insect damage. De novo domestication avoids the complexity of transferring polygenic stress resistance from wild species to crops. Instead, new crops can be created by manipulating major genes in stress-resistant wild species. However, the genetic basis of certain relevant domestication-related traits often involve epistasis and pleiotropy. Furthermore, pan-genome analyses show that structural variation driving gene expression changes has been selected during domestication. A growing body of work suggests that the Solanaceae family, which includes crop species such as tomatoes, potatoes, eggplants, peppers, and tobacco, is a suitable model group to dissect these phenomena and operate changes in wild relatives to improve agronomic traits rapidly with GE. We briefly discuss the prospects of this exciting novel field in the interface between fundamental and applied plant biology and its potential impact in the coming years. •Efficient genome editing (GE) accelerates the domestication of crop wild relatives.•New crops can be rapidly created to withstand drought, flooding, and soil salinity.•De novo domestication enables stress-resistant crops via major gene manipulation.•Epistasis and pleiotropy complicate the creation of domestication-related traits.•Solanaceae family serves as a model for improving traits in wild relatives with GE.