Oxygen-generating biomaterials for cardiovascular engineering: unveiling future discoveries

•Oxygen-generating biomaterials are a biomedical breakthrough, promising to revolutionize cardiovascular care.•Scientific examination shows that these biomaterials significantly improve cardiovascular cell viability and stimulate metabolic activity.•Precision-designed with a scaffold and agents like calcium peroxide, these biomaterials ensure regulated oxygen release.•Envisioning advanced designs, this article notes challenges like material toxicity, emphasizing ongoing research for clinical success. Oxygen-generating biomaterials are emerging as a groundbreaking solution for transforming cardiovascular engineering. These biomaterials generate and release oxygen within various biomedical applications, marking a new frontier in healthcare. Most cardiovascular treatments face a significant challenge, ensuring a consistent oxygen supply to nurture engineered tissues or even implanted devices. Traditional methods relying on passive oxygen diffusion often fall short, hindering functional cardiovascular tissue development. Oxygen-generating biomaterials, incorporating agents like calcium peroxide, provide a controlled oxygen source to the surrounding cells. This innovation potentially enhances cell viability, stimulates growth and boosts metabolic activity crucial for tissue health. Applications include repairing cardiac and vascular tissues, disease modeling, drug testing and personalized medicine, promising tailored treatments. Challenges like material toxicity and oxygen release control need consideration. As research progresses, the use of these innovative biomaterials in clinical translation could reshape cardiovascular healthcare, revolutionizing patient outcomes in heart disease treatment.