Use of a dexamethasone implant to treat macular edema following pars plana vitrectomy and removal of the primary epiretinal membrane

Purpose The purpose of this study was to evaluate the effectiveness and safety of an intravitreal dexamethasone (DEX) implant for the treatment of macular edema (ME) following pars plana vitrectomy (PPV) and removal of the primary epiretinal membrane (ERM) and to assess the impact of the integrity o...

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Veröffentlicht in:International ophthalmology 2024-08, Vol.44 (1), p.340, Article 340
Hauptverfasser: Boz, Ali Altan Ertan, Çelik, Erkan, Atum, Mahmut, Çakır, Burçin, Aksoy, Nilgün Özkan, Özmen, Sedat, Doğan, Emine, Yuvacı, İsa
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Sprache:eng
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Zusammenfassung:Purpose The purpose of this study was to evaluate the effectiveness and safety of an intravitreal dexamethasone (DEX) implant for the treatment of macular edema (ME) following pars plana vitrectomy (PPV) and removal of the primary epiretinal membrane (ERM) and to assess the impact of the integrity of the ellipsoid zone (EZ) and disorganization of the retinal inner layer (DRIL) grade on visual and anatomical outcomes. Methods Forty-two pseudophakic patients who developed ME following PPV and removal of the primary stage 2–3 ERM were included. Patients were divided into two groups when ME was diagnosed via spectral domain optic coherence tomography (SD-OCT). In the DEX group (n = 22), DEX was implanted for the treatment of ME. In the control group (n = 20), only observation was conducted, without any treatment. The best-corrected visual acuity (BCVA) and macular thickness (MT) of the two groups were compared at baseline and 1, 6, and 12 months after DEX implantation. The effects of OCT parameters such as EZ integrity and DRIL grade were also evaluated in terms of decreases in MT and increases in VA in the treatment of ME with DEX implantation. Intraocular pressure (IOP), number of DEX implantations and adverse effects were also recorded. Results While a statistically significant increase in the mean BCVA was observed in the DEX group ( p  
ISSN:1573-2630
0165-5701
1573-2630
DOI:10.1007/s10792-024-03258-8