Polygenic hazard score predicts synaptic and axonal degeneration and cognitive decline in Alzheimer's disease continuum

•PHS shows high diagnostic accuracy in distinguishing AD, MCI, and healthy controls.•PHS can predict cognitive decline and progression of MCI to AD.•PHS impacts the relationship between neurodegenerative biomarkers and cognitive decline. Growth associated protein-43 (GAP-43) and neurofilaments light...

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Veröffentlicht in:	Archives of gerontology and geriatrics 2024-12, Vol.127, p.105576, Article 105576
Hauptverfasser:	Farhadieh, Mohammad-Erfan, Mozafar, Mehrdad, Sanaaee, Saameh, Sodeifi, Parastoo, Kousha, Kiana, Zare, Yeganeh, Zare, Shahab, Maleki Rad, Nooshin, Jamshidi-Goharrizi, Faezeh, Allahverdloo, Mohammad, Rahimi, Arman, Sadeghi, Mohammad, Shafie, Mahan, Mayeli, Mahsa
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - blood Alzheimer Disease - genetics Alzheimer's disease Axons - pathology Biomarkers - blood Case-Control Studies Cognitive Dysfunction - blood Cognitive Dysfunction - genetics Disease Progression Female GAP-43 Protein Growth Associated Protein-43 Humans Male Multifactorial Inheritance Neurofilament Light Chain Neurofilament Proteins - blood Polygenic Hazard Score Synapses - pathology
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