The gut‐immune‐liver axis in patients with alcohol use disorder and clinically low serum zinc levels

The gut‐immune‐liver axis in patients with alcohol use disorder and clinically low serum zinc levels

Background Alcohol use disorder (AUD) with chronic and heavy alcohol consumption causes alcohol‐associated liver disease (ALD). Early‐stage ALD exhibits dyshomeostasis of zinc. We investigated the role of zinc deficiency in gut‐barrier dysfunction, proinflammatory response, hepatocyte injury, and de...

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Veröffentlicht in:Alcohol, clinical & experimental research clinical & experimental research, 2024-09, Vol.48 (9), p.1740-1752
Hauptverfasser: Thakurdesai, Aishwarya, Jha, Suman K., Erinkitola, Iyabo, Said, Aula, Joshi, Thwisha, Schwandt, Melanie L., Parajuli, Dipendra, Singal, Ashwani K., Kong, Maiying, Cave, Matthew C., Vatsalya, Vatsalya
Format: Artikel
Sprache:eng
Schlagworte:
alcohol use disorder
alcohol‐associated liver disease
gut‐barrier dysfunction
gut‐immune‐liver axis
zinc deficiency
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Zusammenfassung:Background Alcohol use disorder (AUD) with chronic and heavy alcohol consumption causes alcohol‐associated liver disease (ALD). Early‐stage ALD exhibits dyshomeostasis of zinc. We investigated the role of zinc deficiency in gut‐barrier dysfunction, proinflammatory response, hepatocyte injury, and death, as well as potential sex differences in AUD patients. Methods Thirty‐nine male and female AUD patients were grouped by normal [≥71 μg/dL (Group 1, number (n) = 26)] and low [
ISSN:2993-7175
2993-7175
DOI:10.1111/acer.15408