Use of Adjuvant Compositions Based on Squalene Ensures Induction of Neutralizing Antibodies against SARS-CoV-2

Squalene-based adjuvant compositions that can provide effective induction of specific humoral immune response have been developed. Recombinant receptor-binding domain (RBD) of surface S-protein of SARS-CoV-2 was used to evaluate the properties of the composition. Immunization of mice with the develo...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2024-06, Vol.177 (2), p.221-224
Hauptverfasser:	Volosnikova, E. A., Volkova, N. V., Ermolaev, V. V., Borgoyakova, M. B., Nesmeyanova, V. S., Zaykovskaya, A. V., Pyankov, O. V., Zaitsev, B. N., Belenkaya, S. V., Isaeva, A. A., Shcherbakov, D. N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants Aluminum Antibodies Antigens Biomedical and Life Sciences Biomedicine Cell Biology Immune response (humoral) Immunization Internal Medicine Laboratory animals Laboratory Medicine Particle size Pathology Pharmacology and Toxicology Protein composition Proteins Severe acute respiratory syndrome coronavirus 2 Squalene Toxicology Vaccines Virology
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Zusammenfassung:	Squalene-based adjuvant compositions that can provide effective induction of specific humoral immune response have been developed. Recombinant receptor-binding domain (RBD) of surface S-protein of SARS-CoV-2 was used to evaluate the properties of the composition. Immunization of mice with the developed squalene-based compositions in combination with RBD allows obtaining high titers of specific antibodies: from 10 5 to 2×10 6 . The blood sera from immunized mice exhibit neutralizing activity against SARS-CoV-2 Delta variant (B.1.617.2) with a titer up to 1:2000.
ISSN:	0007-4888 1573-8221 1573-8221
DOI:	10.1007/s10517-024-06160-6