Angiotensin converting enzyme inhibitory hydrolysate and peptide fractions from chicken skin collagen, as modulators of lipid accumulation in adipocytes 3 T3-L1, after in vitro gastrointestinal digestion
Inhibitory activity against angiotensin-converting enzyme (IAACE) by chicken skin collagen hydrolysate (CSCH) and their peptide fractions before and after in-vitro gastrointestinal digestion, were evaluated; as well as their ability to modulate lipid accumulation in 3 T3-L1 adipocytes. Before digest...
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| Veröffentlicht in: | Food chemistry 2024-12, Vol.460 (Pt 2), p.140551, Article 140551 |
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| creator | González-Noriega, Julio Alfonso Valenzuela-Melendres, Martín Hernández-Mendoza, Adrián Astiazarán-García, Humberto Islava-Lagarda, Thalia Tortoledo-Ortiz, Orlando Huerta-Ocampo, José Ángel de La Garza, Ana Laura Peña-Ramos, Etna Aída |
| description | Inhibitory activity against angiotensin-converting enzyme (IAACE) by chicken skin collagen hydrolysate (CSCH) and their peptide fractions before and after in-vitro gastrointestinal digestion, were evaluated; as well as their ability to modulate lipid accumulation in 3 T3-L1 adipocytes. Before digestion, peptide fraction |
| doi_str_mv | 10.1016/j.foodchem.2024.140551 |
| format | Article |
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•Chicken skin collagen fraction <1 kDa was the most effective inhibitor of ACE•ACE inhibition by chicken collagen peptides <1 kDa was stable post-digestion•Digested chicken collagen peptides reduced lipid content in adipocytes•Chicken skin collagen's antiobesity effect was better when added in preadipocytes•Chicken skin collagen is a good source of potential antiobesogenic peptides]]></description><identifier>ISSN: 0308-8146</identifier><identifier>ISSN: 1873-7072</identifier><identifier>EISSN: 1873-7072</identifier><identifier>DOI: 10.1016/j.foodchem.2024.140551</identifier><identifier>PMID: 39083965</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>3T3-L1 Cells ; 3 T3-L1 adipocyte ; Adipocytes - drug effects ; Adipocytes - metabolism ; Angiotensin converting enzyme ; Angiotensin-Converting Enzyme Inhibitors - chemistry ; Angiotensin-Converting Enzyme Inhibitors - metabolism ; Angiotensin-Converting Enzyme Inhibitors - pharmacology ; Animals ; Chickens - metabolism ; Collagen - chemistry ; Collagen - metabolism ; Collagen hydrolysate ; Digestion ; Gastrointestinal digestion ; Gastrointestinal Tract - metabolism ; Humans ; Lipid Metabolism - drug effects ; Mice ; Peptides - chemistry ; Peptides - metabolism ; Peptides - pharmacology ; Peptides fractions ; Peptidyl-Dipeptidase A - chemistry ; Peptidyl-Dipeptidase A - metabolism ; Protein Hydrolysates - chemistry ; Protein Hydrolysates - metabolism ; Protein Hydrolysates - pharmacology ; Skin - chemistry ; Skin - metabolism</subject><ispartof>Food chemistry, 2024-12, Vol.460 (Pt 2), p.140551, Article 140551</ispartof><rights>2024</rights><rights>Copyright © 2024. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c245t-b765de1480d0e6d3566cae0cf8b549a62de43f68deb2c1953764424bff6bd4503</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0308814624022015$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39083965$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>González-Noriega, Julio Alfonso</creatorcontrib><creatorcontrib>Valenzuela-Melendres, Martín</creatorcontrib><creatorcontrib>Hernández-Mendoza, Adrián</creatorcontrib><creatorcontrib>Astiazarán-García, Humberto</creatorcontrib><creatorcontrib>Islava-Lagarda, Thalia</creatorcontrib><creatorcontrib>Tortoledo-Ortiz, Orlando</creatorcontrib><creatorcontrib>Huerta-Ocampo, José Ángel</creatorcontrib><creatorcontrib>de La Garza, Ana Laura</creatorcontrib><creatorcontrib>Peña-Ramos, Etna Aída</creatorcontrib><title>Angiotensin converting enzyme inhibitory hydrolysate and peptide fractions from chicken skin collagen, as modulators of lipid accumulation in adipocytes 3 T3-L1, after in vitro gastrointestinal digestion</title><title>Food chemistry</title><addtitle>Food Chem</addtitle><description><![CDATA[Inhibitory activity against angiotensin-converting enzyme (IAACE) by chicken skin collagen hydrolysate (CSCH) and their peptide fractions before and after in-vitro gastrointestinal digestion, were evaluated; as well as their ability to modulate lipid accumulation in 3 T3-L1 adipocytes. Before digestion, peptide fraction <1 kDa (F4) showed the highest IAACE (p < 0.05) followed by CSCH. After these samples were digested, F4 presented an IAACE with IC50 similar to its digest (DF4) (188.84 and 220.03 μg/mL, respectively), which was 2-fold lower (p < 0.05) than IC50 of fraction <1 kDa from post-digested hydrolysate (FDH) (388.57 μg/mL). Nine peptides were identified as the potential ACE inhibitors in F4 and DF4. Addition of DF4 (800 μg/mL) reduced(p < 0.05) lipid accumulation by 83% within preadipocytes. A 45–60% reduction of lipid accumulation within differentiated adipocytes was obtained by adding FDH and DF4 (regardless the concentration). These results, digested CSCH and F4 with IAACE may be considered as potential adjuvants for obesity treatment.
•Chicken skin collagen fraction <1 kDa was the most effective inhibitor of ACE•ACE inhibition by chicken collagen peptides <1 kDa was stable post-digestion•Digested chicken collagen peptides reduced lipid content in adipocytes•Chicken skin collagen's antiobesity effect was better when added in preadipocytes•Chicken skin collagen is a good source of potential antiobesogenic peptides]]></description><subject>3T3-L1 Cells</subject><subject>3 T3-L1 adipocyte</subject><subject>Adipocytes - drug effects</subject><subject>Adipocytes - metabolism</subject><subject>Angiotensin converting enzyme</subject><subject>Angiotensin-Converting Enzyme Inhibitors - chemistry</subject><subject>Angiotensin-Converting Enzyme Inhibitors - metabolism</subject><subject>Angiotensin-Converting Enzyme Inhibitors - pharmacology</subject><subject>Animals</subject><subject>Chickens - metabolism</subject><subject>Collagen - chemistry</subject><subject>Collagen - metabolism</subject><subject>Collagen hydrolysate</subject><subject>Digestion</subject><subject>Gastrointestinal digestion</subject><subject>Gastrointestinal Tract - metabolism</subject><subject>Humans</subject><subject>Lipid Metabolism - drug effects</subject><subject>Mice</subject><subject>Peptides - chemistry</subject><subject>Peptides - metabolism</subject><subject>Peptides - pharmacology</subject><subject>Peptides fractions</subject><subject>Peptidyl-Dipeptidase A - chemistry</subject><subject>Peptidyl-Dipeptidase A - metabolism</subject><subject>Protein Hydrolysates - chemistry</subject><subject>Protein Hydrolysates - metabolism</subject><subject>Protein Hydrolysates - pharmacology</subject><subject>Skin - chemistry</subject><subject>Skin - metabolism</subject><issn>0308-8146</issn><issn>1873-7072</issn><issn>1873-7072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUc1u1DAQjhCILoVXqHzkQBY7cZzsjariT1qJSzlbjj3Jzjaxg-2slD4Nz8K5D1WHbbniy4zG34_HX5ZdMbpllImPx23nnNEHGLcFLfiWcVpV7EW2YU1d5jWti5fZhpa0yRvGxUX2JoQjpbSgrHmdXZQ72pQ7UW2yh2vbo4tgA1qinT2Bj2h7AvZ-GYGgPWCL0fmFHBbj3bAEFYEoa8gEU0QDpPNKR3Q2pM6NRB9Q34El4e6v4DCoHuwHogIZnZkHlbQCcR0ZcEJDlNbzuE6TQDIjyuDk9BIhkPLP79sy37PE7SL49faE0TvSq5AK2gRKT1UDMdivrbNvs1edGgK8e6qX2c8vn29vvuX7H1-_31zvc13wKuZtLSoDjDfUUBCmrITQCqjumrbiOyUKA7zsRGOgLTTbVWUtOC9423WiNbyi5WX2_qw7efdrTt5yxKAh7WrBzUGmbxe7iqeToOIM1d6F4KGTk8dR-UUyKtck5VE-JynXJOU5yUS8evKY2xHMP9pzdAnw6QyAtOkJwcugEawGgx50lMbh_zweAQ5puaA</recordid><startdate>20241201</startdate><enddate>20241201</enddate><creator>González-Noriega, Julio Alfonso</creator><creator>Valenzuela-Melendres, Martín</creator><creator>Hernández-Mendoza, Adrián</creator><creator>Astiazarán-García, Humberto</creator><creator>Islava-Lagarda, Thalia</creator><creator>Tortoledo-Ortiz, Orlando</creator><creator>Huerta-Ocampo, José Ángel</creator><creator>de La Garza, Ana Laura</creator><creator>Peña-Ramos, Etna Aída</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20241201</creationdate><title>Angiotensin converting enzyme inhibitory hydrolysate and peptide fractions from chicken skin collagen, as modulators of lipid accumulation in adipocytes 3 T3-L1, after in vitro gastrointestinal digestion</title><author>González-Noriega, Julio Alfonso ; Valenzuela-Melendres, Martín ; Hernández-Mendoza, Adrián ; Astiazarán-García, Humberto ; Islava-Lagarda, Thalia ; Tortoledo-Ortiz, Orlando ; Huerta-Ocampo, José Ángel ; de La Garza, Ana Laura ; Peña-Ramos, Etna Aída</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c245t-b765de1480d0e6d3566cae0cf8b549a62de43f68deb2c1953764424bff6bd4503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>3T3-L1 Cells</topic><topic>3 T3-L1 adipocyte</topic><topic>Adipocytes - drug effects</topic><topic>Adipocytes - metabolism</topic><topic>Angiotensin converting enzyme</topic><topic>Angiotensin-Converting Enzyme Inhibitors - chemistry</topic><topic>Angiotensin-Converting Enzyme Inhibitors - metabolism</topic><topic>Angiotensin-Converting Enzyme Inhibitors - pharmacology</topic><topic>Animals</topic><topic>Chickens - metabolism</topic><topic>Collagen - chemistry</topic><topic>Collagen - metabolism</topic><topic>Collagen hydrolysate</topic><topic>Digestion</topic><topic>Gastrointestinal digestion</topic><topic>Gastrointestinal Tract - metabolism</topic><topic>Humans</topic><topic>Lipid Metabolism - drug effects</topic><topic>Mice</topic><topic>Peptides - chemistry</topic><topic>Peptides - metabolism</topic><topic>Peptides - pharmacology</topic><topic>Peptides fractions</topic><topic>Peptidyl-Dipeptidase A - chemistry</topic><topic>Peptidyl-Dipeptidase A - metabolism</topic><topic>Protein Hydrolysates - chemistry</topic><topic>Protein Hydrolysates - metabolism</topic><topic>Protein Hydrolysates - pharmacology</topic><topic>Skin - chemistry</topic><topic>Skin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>González-Noriega, Julio Alfonso</creatorcontrib><creatorcontrib>Valenzuela-Melendres, Martín</creatorcontrib><creatorcontrib>Hernández-Mendoza, Adrián</creatorcontrib><creatorcontrib>Astiazarán-García, Humberto</creatorcontrib><creatorcontrib>Islava-Lagarda, Thalia</creatorcontrib><creatorcontrib>Tortoledo-Ortiz, Orlando</creatorcontrib><creatorcontrib>Huerta-Ocampo, José Ángel</creatorcontrib><creatorcontrib>de La Garza, Ana Laura</creatorcontrib><creatorcontrib>Peña-Ramos, Etna Aída</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>González-Noriega, Julio Alfonso</au><au>Valenzuela-Melendres, Martín</au><au>Hernández-Mendoza, Adrián</au><au>Astiazarán-García, Humberto</au><au>Islava-Lagarda, Thalia</au><au>Tortoledo-Ortiz, Orlando</au><au>Huerta-Ocampo, José Ángel</au><au>de La Garza, Ana Laura</au><au>Peña-Ramos, Etna Aída</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Angiotensin converting enzyme inhibitory hydrolysate and peptide fractions from chicken skin collagen, as modulators of lipid accumulation in adipocytes 3 T3-L1, after in vitro gastrointestinal digestion</atitle><jtitle>Food chemistry</jtitle><addtitle>Food Chem</addtitle><date>2024-12-01</date><risdate>2024</risdate><volume>460</volume><issue>Pt 2</issue><spage>140551</spage><pages>140551-</pages><artnum>140551</artnum><issn>0308-8146</issn><issn>1873-7072</issn><eissn>1873-7072</eissn><abstract><![CDATA[Inhibitory activity against angiotensin-converting enzyme (IAACE) by chicken skin collagen hydrolysate (CSCH) and their peptide fractions before and after in-vitro gastrointestinal digestion, were evaluated; as well as their ability to modulate lipid accumulation in 3 T3-L1 adipocytes. Before digestion, peptide fraction <1 kDa (F4) showed the highest IAACE (p < 0.05) followed by CSCH. After these samples were digested, F4 presented an IAACE with IC50 similar to its digest (DF4) (188.84 and 220.03 μg/mL, respectively), which was 2-fold lower (p < 0.05) than IC50 of fraction <1 kDa from post-digested hydrolysate (FDH) (388.57 μg/mL). Nine peptides were identified as the potential ACE inhibitors in F4 and DF4. Addition of DF4 (800 μg/mL) reduced(p < 0.05) lipid accumulation by 83% within preadipocytes. A 45–60% reduction of lipid accumulation within differentiated adipocytes was obtained by adding FDH and DF4 (regardless the concentration). These results, digested CSCH and F4 with IAACE may be considered as potential adjuvants for obesity treatment.
•Chicken skin collagen fraction <1 kDa was the most effective inhibitor of ACE•ACE inhibition by chicken collagen peptides <1 kDa was stable post-digestion•Digested chicken collagen peptides reduced lipid content in adipocytes•Chicken skin collagen's antiobesity effect was better when added in preadipocytes•Chicken skin collagen is a good source of potential antiobesogenic peptides]]></abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>39083965</pmid><doi>10.1016/j.foodchem.2024.140551</doi></addata></record> |
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| subjects | 3T3-L1 Cells 3 T3-L1 adipocyte Adipocytes - drug effects Adipocytes - metabolism Angiotensin converting enzyme Angiotensin-Converting Enzyme Inhibitors - chemistry Angiotensin-Converting Enzyme Inhibitors - metabolism Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals Chickens - metabolism Collagen - chemistry Collagen - metabolism Collagen hydrolysate Digestion Gastrointestinal digestion Gastrointestinal Tract - metabolism Humans Lipid Metabolism - drug effects Mice Peptides - chemistry Peptides - metabolism Peptides - pharmacology Peptides fractions Peptidyl-Dipeptidase A - chemistry Peptidyl-Dipeptidase A - metabolism Protein Hydrolysates - chemistry Protein Hydrolysates - metabolism Protein Hydrolysates - pharmacology Skin - chemistry Skin - metabolism |
| title | Angiotensin converting enzyme inhibitory hydrolysate and peptide fractions from chicken skin collagen, as modulators of lipid accumulation in adipocytes 3 T3-L1, after in vitro gastrointestinal digestion |
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