Bevacizumab for Brain Radiation Necrosis in Patients With Nonsquamous Nonsmall Cell Lung Cancer

•The incidence of brain radiation necrosis is increasing in NSCLC patients undergoing radiotherapy for brain metastases.•[11C] methionine–PET and MRS are valuable tools for diagnosing brain radiation necrosis.•Bevacizumab is an effective treatment for brain radiation necrosis in patients with nonsqu...

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Veröffentlicht in:	Clinical lung cancer 2024-09, Vol.25 (6), p.581-586.e3
Hauptverfasser:	Shibahara, Daisuke, Tanaka, Kentaro, Togao, Osamu, Shiraishi, Yoshimasa, Yoneshima, Yasuto, Iwama, Eiji, Yoshitake, Tadamasa, Ishigami, Kousei, Okamoto, Isamu
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antineoplastic Agents, Immunological - adverse effects Antineoplastic Agents, Immunological - therapeutic use Bevacizumab - therapeutic use Brain - drug effects Brain - pathology Brain metastasis Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - radiotherapy Female Humans Lung Neoplasms - drug therapy Lung Neoplasms - pathology Lung Neoplasms - radiotherapy Male Methionine Middle Aged MRS Necrosis NSCLC Radiation Injuries - etiology VEGF
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Zusammenfassung:	•The incidence of brain radiation necrosis is increasing in NSCLC patients undergoing radiotherapy for brain metastases.•[11C] methionine–PET and MRS are valuable tools for diagnosing brain radiation necrosis.•Bevacizumab is an effective treatment for brain radiation necrosis in patients with nonsquamous NSCLC.
ISSN:	1525-7304 1938-0690 1938-0690
DOI:	10.1016/j.cllc.2024.06.010