Meta analysis of radiofrequency ablation versus surgical resection in small and large nodule of hepatocellular carcinoma

Although studies have indicated comparable outcomes between RFA and surgical resection in early HCC, there is still unclear evidence of benefit in larger tumor sizes. This study aimed to assess the efficacy and safety of RFA versus surgical resection in HCC patients, considering nodule size with a c...

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Veröffentlicht in:	HPB (Oxford, England) England), 2024-10, Vol.26 (10), p.1216-1228
Hauptverfasser:	Gani, Rino A., Teressa, Maria, Budiman, Refael A., Kalista, Kemal F., Lesmana, Cosmas Rinaldi A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - surgery Hepatectomy - methods Humans Liver Neoplasms - mortality Liver Neoplasms - pathology Liver Neoplasms - surgery Radiofrequency Ablation - adverse effects Risk Factors Time Factors Treatment Outcome Tumor Burden
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Zusammenfassung:	Although studies have indicated comparable outcomes between RFA and surgical resection in early HCC, there is still unclear evidence of benefit in larger tumor sizes. This study aimed to assess the efficacy and safety of RFA versus surgical resection in HCC patients, considering nodule size with a cutoff at 3 cm. A comprehensive search of multiple databases was conducted. The systematic review and meta-analysis followed the PRISMA guidelines. Surgical resection showed superior OS (HR = 1.18, 95% CI: 1.11–1.27, p = 0.008) and RFS (HR = 1.17, 95% CI: 1.11–1.25, p
ISSN:	1365-182X 1477-2574 1477-2574
DOI:	10.1016/j.hpb.2024.06.009