Baseline Blood CD8 + T Cell Activation Potency Discriminates Responders from Non-Responders to Immune Checkpoint Inhibition Combined with Stereotactic Radiotherapy in Non-Small-Cell Lung Cancer

Tumor-infiltrating immune cells have been correlated with prognosis for patients treated with immune checkpoint inhibitor (ICI) treatment of various cancers. However, no robust biomarker has been described to predict treatment response yet. We hypothesized that the activation potency of circulating...

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Veröffentlicht in:	Cancers 2024-07, Vol.16 (14), p.2592
Hauptverfasser:	Kievit, Hanneke, Muntinghe-Wagenaar, M Benthe, Abdulahad, Wayel H, Rutgers, Abraham, Hijmering-Kappelle, Lucie B M, Hiddinga, Birgitta I, Ubbels, J Fred, Wijsman, Robin, van der Leij, Marcel J, Bijzet, Johan, Groen, Harry J M, Kerstjens, Huib A M, van der Wekken, Anthonie J, Kroesen, Bart-Jan, Hiltermann, T Jeroen N
Format:	Artikel
Sprache:	eng
Schlagworte:	B cells Biomarkers BLyS protein CD4 antigen CD69 antigen CD8 antigen Cell activation Clinical medicine Cytokines Ethylenediaminetetraacetic acid Flow cytometry Immune checkpoint inhibitors Immune system Interleukin 2 Interleukin 2 receptors Intracellular Lung cancer Lung cancer, Non-small cell Lymphocytes Lymphocytes T Medical equipment and supplies industry Medical prognosis Medical test kit industry Neutrophils Non-small cell lung carcinoma Patients Pemetrexed Peripheral blood Radiation therapy Radiotherapy Serum levels Small cell lung carcinoma Staphylococcal enterotoxin B T cells Tumor-infiltrating lymphocytes Tumors γ-Interferon
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Zusammenfassung:	Tumor-infiltrating immune cells have been correlated with prognosis for patients treated with immune checkpoint inhibitor (ICI) treatment of various cancers. However, no robust biomarker has been described to predict treatment response yet. We hypothesized that the activation potency of circulating T cells may predict response to ICI treatment. An exploratory analysis was conducted to investigate the association between the response to immune checkpoint inhibition (ICI) combined with stereotactic radiotherapy (SBRT) and the potency of circulating T cells to be activated. Blood-derived lymphocytes from 14 patients were stimulated ex vivo with, among others, Staphylococcal enterotoxin B (SEB) and compared to healthy controls (HCs). Patients were grouped into responders (>median progression free survival (PFS)) and non-responders (
ISSN:	2072-6694 2072-6694
DOI:	10.3390/cancers16142592