Abnormalities in copper status associated with diminished ovarian reserve: A case–control and cross‐sectional study

Objective This study aimed to illustrate the copper status of diminished ovarian reserve in Chinese women, especially the effects of copper, ceruloplasmin, non‐ceruloplasmin‐bound copper (NCC) and CuZn superoxide dismutase (SOD1). Methods This case–control, cross‐sectional investigation included women with diminished ovarian reserve (DOR group, n = 35) and matched normal ovarian reserve (NOR group, n = 35). The serum levels of copper, ceruloplasmin, NCC, SOD1, follicle‐stimulating hormone, luteinizing hormone, estradiol, testosterone, and anti‐Müllerian hormone were tested and analyzed. Results The serum copper concentrations (60.88%), NCC (54.75%) and SOD1 (54.75%) in the DOR group were significantly higher than those in the NOR group (all P