Enhancing survival after ionizing radiation exposure through mitigation of pyroptosis

•Pyroptosis is implicated in the pathogenesis of ionizing radiation so we investigated cell type involvement in a mouse model.•Pyroptotic markers were expressed highly at day 3 post total body irradiation (TBI) predominantly in immune cells from ileum.•We investigated the effectiveness of MCC950, a...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular basis of disease 2024-10, Vol.1870 (7), p.167434, Article 167434
Hauptverfasser:	Richter, Brandon, Epperly, Michael, Tyurina, Yulia, Shurin, Galina, Johnson, Carla, Korkmaz, Aybike, Gao, Yuan, Scott, Julie, Greenberger, Joel, Kagan, Valerian, Bayır, Hülya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Death Cell Survival - radiation effects Humans Immunology Inflammation Pharmacology Pyroptosis Pyroptosis - radiation effects Radiation Radiation, Ionizing
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Zusammenfassung:	•Pyroptosis is implicated in the pathogenesis of ionizing radiation so we investigated cell type involvement in a mouse model.•Pyroptotic markers were expressed highly at day 3 post total body irradiation (TBI) predominantly in immune cells from ileum.•We investigated the effectiveness of MCC950, a pyroptosis inhibitor, in our model showing survival benefit at 50 mg/kg.•Treatment with MCC950 showed elevation in full-length mediator IL-1β in ileum and decreased level of cleaved IL-1β in spleen.
ISSN:	0925-4439 1879-260X 1879-260X
DOI:	10.1016/j.bbadis.2024.167434