Case study: cremophor EL-based liquid formulations as simple substitutes for amorphous solid dispersions in early preclinical in vivo studies
The objective of the present case study was to increase the exposure of the poorly soluble crystalline compound A. Mice received 10 mg/kg of crystalline compound A formulated in eight different cosolvent, oil, and cyclodextrin mixtures. In all cases, AUC0-24h and maximum blood/plasma concentration (...
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| Veröffentlicht in: | Journal of pharmacy and pharmacology 2024-07 |
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| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | The objective of the present case study was to increase the exposure of the poorly soluble crystalline compound A.
Mice received 10 mg/kg of crystalline compound A formulated in eight different cosolvent, oil, and cyclodextrin mixtures.
In all cases, AUC0-24h and maximum blood/plasma concentration (Cmax) were in the range of 6-16 µM × h and |
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| ISSN: | 0022-3573 2042-7158 2042-7158 |
| DOI: | 10.1093/jpp/rgae099 |