Protective effects of 3, 4‐dihydroxybenzoic acid on myocardial infarction induced by isoproterenol in rats
Despite considerable advances in interventions and treatment, there is a high mortality rate in patients with myocardial infarction (MI). This is the first study to investigate the protective effects of 3, 4‐dihydroxybenzoic acid against isoproterenol induced MI in rats. MI was induced by isoprotere...
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| description | Despite considerable advances in interventions and treatment, there is a high mortality rate in patients with myocardial infarction (MI). This is the first study to investigate the protective effects of 3, 4‐dihydroxybenzoic acid against isoproterenol induced MI in rats. MI was induced by isoproterenol (100‐mg/kg body weight) in rats. Then, rats were treated with 3, 4‐dihydroxybenzoic acid (16‐mg/kg body weight) for 2 weeks. Serum creatine kinase‐MB, cardiac troponin‐T, cardiac troponin‐I, and heart thiobarbituric acid reactive substances were significantly (p |
| doi_str_mv | 10.1002/jbt.23773 |
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3, 4‐dihydroxy benzoic acid's effects on myocardial infarction were appraised. It reduced lipid peroxidation in rats. 3, 4‐dihydroxy benzoic acid improved antioxidants in rats. It also reduced nuclear factor‐κB, tumor necrosis factor‐alpha, interleukin‐1 beta, and Interleukin‐6, and raised interleukin‐10. 3, 4‐dihydroxy benzoic acid's antioxidant and anti‐inflammatory mechanisms.]]></description><identifier>ISSN: 1095-6670</identifier><identifier>ISSN: 1099-0461</identifier><identifier>EISSN: 1099-0461</identifier><identifier>DOI: 10.1002/jbt.23773</identifier><identifier>PMID: 39030868</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>3, 4‐dihydroxybenzoic acid ; Acids ; Animals ; antioxidant ; Body weight ; Catalase ; Creatine ; Creatine kinase ; Cytokines ; Dihydroxybenzoic acid ; Gentisates - metabolism ; Gentisates - pharmacology ; Heart ; Heart attacks ; Homocysteine ; Hydroxybenzoates - pharmacology ; Interleukin 6 ; Interleukins ; Isoproterenol ; Isoproterenol - toxicity ; Kinases ; Male ; Myocardial infarction ; Myocardial Infarction - chemically induced ; Myocardial Infarction - metabolism ; Myocardial Infarction - prevention & control ; Myocardium - metabolism ; Myocardium - pathology ; Oxidative stress ; Oxidative Stress - drug effects ; Rats ; Rats, Sprague-Dawley ; Reverse transcription ; Superoxide dismutase ; Thiobarbituric acid ; Troponin ; Troponin I - blood ; Troponin I - metabolism</subject><ispartof>Journal of biochemical and molecular toxicology, 2024-08, Vol.38 (8), p.e23773-n/a</ispartof><rights>2024 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2433-48d32b647dc8f6d291ba353024d00294843880988c3f9f1f29fa75eede769aa73</cites><orcidid>0000-0002-6840-4074</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjbt.23773$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjbt.23773$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39030868$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vincent, Sikha</creatorcontrib><creatorcontrib>Stanely, Shervin Prince</creatorcontrib><creatorcontrib>Ponnian, Stanely Mainzen Prince</creatorcontrib><title>Protective effects of 3, 4‐dihydroxybenzoic acid on myocardial infarction induced by isoproterenol in rats</title><title>Journal of biochemical and molecular toxicology</title><addtitle>J Biochem Mol Toxicol</addtitle><description><![CDATA[Despite considerable advances in interventions and treatment, there is a high mortality rate in patients with myocardial infarction (MI). This is the first study to investigate the protective effects of 3, 4‐dihydroxybenzoic acid against isoproterenol induced MI in rats. MI was induced by isoproterenol (100‐mg/kg body weight) in rats. Then, rats were treated with 3, 4‐dihydroxybenzoic acid (16‐mg/kg body weight) for 2 weeks. Serum creatine kinase‐MB, cardiac troponin‐T, cardiac troponin‐I, and heart thiobarbituric acid reactive substances were significantly (p < 0.05) increased and heart superoxide dismutase and catalase activities were significantly (p < 0.05) reduced in isoproterenol‐induced myocardial infarcted rats. Isoproterenol induction significantly (p < 0.05) elevated the plasma homocysteine and serum high sensitivity‐C‐reactive protein levels. Furthermore, an enzyme‐linked immunosorbent assay, reverse transcription polymerase chain study, and immunohistochemical (IHC) staining revealed significantly (p < 0.05) elevated levels and expression of serum/myocardial nuclear factor‐κB, tumor necrosis factor‐alpha, interleukin‐1 beta, and Interleukin‐6 and significantly (p < 0.05) reduced levels/expression of serum/myocardial interleukin‐10 in myocardial infarcted rats. Nevertheless, isoproterenol‐induced rats treated with 3, 4‐dihydroxybenzoic acid considerably (p < 0.05) attenuated all the biochemical, molecular, and IHC parameters investigated and inhibited oxidative stress and inflammation and protected the heart, through its antioxidant and anti‐inflammatory mechanisms.
3, 4‐dihydroxy benzoic acid's effects on myocardial infarction were appraised. It reduced lipid peroxidation in rats. 3, 4‐dihydroxy benzoic acid improved antioxidants in rats. It also reduced nuclear factor‐κB, tumor necrosis factor‐alpha, interleukin‐1 beta, and Interleukin‐6, and raised interleukin‐10. 3, 4‐dihydroxy benzoic acid's antioxidant and anti‐inflammatory mechanisms.]]></description><subject>3, 4‐dihydroxybenzoic acid</subject><subject>Acids</subject><subject>Animals</subject><subject>antioxidant</subject><subject>Body weight</subject><subject>Catalase</subject><subject>Creatine</subject><subject>Creatine kinase</subject><subject>Cytokines</subject><subject>Dihydroxybenzoic acid</subject><subject>Gentisates - metabolism</subject><subject>Gentisates - pharmacology</subject><subject>Heart</subject><subject>Heart attacks</subject><subject>Homocysteine</subject><subject>Hydroxybenzoates - pharmacology</subject><subject>Interleukin 6</subject><subject>Interleukins</subject><subject>Isoproterenol</subject><subject>Isoproterenol - toxicity</subject><subject>Kinases</subject><subject>Male</subject><subject>Myocardial infarction</subject><subject>Myocardial Infarction - chemically induced</subject><subject>Myocardial Infarction - metabolism</subject><subject>Myocardial Infarction - prevention & control</subject><subject>Myocardium - metabolism</subject><subject>Myocardium - pathology</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reverse transcription</subject><subject>Superoxide dismutase</subject><subject>Thiobarbituric acid</subject><subject>Troponin</subject><subject>Troponin I - blood</subject><subject>Troponin I - metabolism</subject><issn>1095-6670</issn><issn>1099-0461</issn><issn>1099-0461</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctKxDAUhoMo3he-gATcKFgnTdI0WergFUEXui5pLpih02jSqnXlI_iMPomZGXUhuMohfHzn8gOwk6OjHCE8mtTdESZlSZbAeo6EyBBl-fK8LjLGSrQGNmKcIIQKURarYI0IRBBnfB00t8F3RnXu2UBjbaoi9BaSQ0g_3z-0exh08K9Dbdo37xSUymnoWzgdvJJBO9lA11oZkiD9ulb3ymhYD9BF_zgzB9P6GQOD7OIWWLGyiWb7-90E92end-OL7Prm_HJ8fJ0pTAnJKNcE14yWWnHLNBZ5LUlBEKY6bSsop4RzJDhXxAqbWyysLAtjtCmZkLIkm2B_4U0jPPUmdtXURWWaRrbG97FKu2NRCEZZQvf-oBPfhzZNlyiBC5yaiUQdLCgVfIzB2OoxuKkMQ5WjahZBlSKo5hEkdvfb2NdTo3_Jn5snYLQAXlxjhv9N1dXJ3UL5BbBHkM4</recordid><startdate>202408</startdate><enddate>202408</enddate><creator>Vincent, Sikha</creator><creator>Stanely, Shervin Prince</creator><creator>Ponnian, Stanely Mainzen Prince</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6840-4074</orcidid></search><sort><creationdate>202408</creationdate><title>Protective effects of 3, 4‐dihydroxybenzoic acid on myocardial infarction induced by isoproterenol in rats</title><author>Vincent, Sikha ; Stanely, Shervin Prince ; Ponnian, Stanely Mainzen Prince</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2433-48d32b647dc8f6d291ba353024d00294843880988c3f9f1f29fa75eede769aa73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>3, 4‐dihydroxybenzoic acid</topic><topic>Acids</topic><topic>Animals</topic><topic>antioxidant</topic><topic>Body weight</topic><topic>Catalase</topic><topic>Creatine</topic><topic>Creatine kinase</topic><topic>Cytokines</topic><topic>Dihydroxybenzoic acid</topic><topic>Gentisates - metabolism</topic><topic>Gentisates - pharmacology</topic><topic>Heart</topic><topic>Heart attacks</topic><topic>Homocysteine</topic><topic>Hydroxybenzoates - pharmacology</topic><topic>Interleukin 6</topic><topic>Interleukins</topic><topic>Isoproterenol</topic><topic>Isoproterenol - toxicity</topic><topic>Kinases</topic><topic>Male</topic><topic>Myocardial infarction</topic><topic>Myocardial Infarction - chemically induced</topic><topic>Myocardial Infarction - metabolism</topic><topic>Myocardial Infarction - prevention & control</topic><topic>Myocardium - metabolism</topic><topic>Myocardium - pathology</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reverse transcription</topic><topic>Superoxide dismutase</topic><topic>Thiobarbituric acid</topic><topic>Troponin</topic><topic>Troponin I - blood</topic><topic>Troponin I - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vincent, Sikha</creatorcontrib><creatorcontrib>Stanely, Shervin Prince</creatorcontrib><creatorcontrib>Ponnian, Stanely Mainzen Prince</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biochemical and molecular toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vincent, Sikha</au><au>Stanely, Shervin Prince</au><au>Ponnian, Stanely Mainzen Prince</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective effects of 3, 4‐dihydroxybenzoic acid on myocardial infarction induced by isoproterenol in rats</atitle><jtitle>Journal of biochemical and molecular toxicology</jtitle><addtitle>J Biochem Mol Toxicol</addtitle><date>2024-08</date><risdate>2024</risdate><volume>38</volume><issue>8</issue><spage>e23773</spage><epage>n/a</epage><pages>e23773-n/a</pages><issn>1095-6670</issn><issn>1099-0461</issn><eissn>1099-0461</eissn><abstract><![CDATA[Despite considerable advances in interventions and treatment, there is a high mortality rate in patients with myocardial infarction (MI). This is the first study to investigate the protective effects of 3, 4‐dihydroxybenzoic acid against isoproterenol induced MI in rats. MI was induced by isoproterenol (100‐mg/kg body weight) in rats. Then, rats were treated with 3, 4‐dihydroxybenzoic acid (16‐mg/kg body weight) for 2 weeks. Serum creatine kinase‐MB, cardiac troponin‐T, cardiac troponin‐I, and heart thiobarbituric acid reactive substances were significantly (p < 0.05) increased and heart superoxide dismutase and catalase activities were significantly (p < 0.05) reduced in isoproterenol‐induced myocardial infarcted rats. Isoproterenol induction significantly (p < 0.05) elevated the plasma homocysteine and serum high sensitivity‐C‐reactive protein levels. Furthermore, an enzyme‐linked immunosorbent assay, reverse transcription polymerase chain study, and immunohistochemical (IHC) staining revealed significantly (p < 0.05) elevated levels and expression of serum/myocardial nuclear factor‐κB, tumor necrosis factor‐alpha, interleukin‐1 beta, and Interleukin‐6 and significantly (p < 0.05) reduced levels/expression of serum/myocardial interleukin‐10 in myocardial infarcted rats. Nevertheless, isoproterenol‐induced rats treated with 3, 4‐dihydroxybenzoic acid considerably (p < 0.05) attenuated all the biochemical, molecular, and IHC parameters investigated and inhibited oxidative stress and inflammation and protected the heart, through its antioxidant and anti‐inflammatory mechanisms.
3, 4‐dihydroxy benzoic acid's effects on myocardial infarction were appraised. It reduced lipid peroxidation in rats. 3, 4‐dihydroxy benzoic acid improved antioxidants in rats. It also reduced nuclear factor‐κB, tumor necrosis factor‐alpha, interleukin‐1 beta, and Interleukin‐6, and raised interleukin‐10. 3, 4‐dihydroxy benzoic acid's antioxidant and anti‐inflammatory mechanisms.]]></abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>39030868</pmid><doi>10.1002/jbt.23773</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0002-6840-4074</orcidid></addata></record> |
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| subjects | 3, 4‐dihydroxybenzoic acid Acids Animals antioxidant Body weight Catalase Creatine Creatine kinase Cytokines Dihydroxybenzoic acid Gentisates - metabolism Gentisates - pharmacology Heart Heart attacks Homocysteine Hydroxybenzoates - pharmacology Interleukin 6 Interleukins Isoproterenol Isoproterenol - toxicity Kinases Male Myocardial infarction Myocardial Infarction - chemically induced Myocardial Infarction - metabolism Myocardial Infarction - prevention & control Myocardium - metabolism Myocardium - pathology Oxidative stress Oxidative Stress - drug effects Rats Rats, Sprague-Dawley Reverse transcription Superoxide dismutase Thiobarbituric acid Troponin Troponin I - blood Troponin I - metabolism |
| title | Protective effects of 3, 4‐dihydroxybenzoic acid on myocardial infarction induced by isoproterenol in rats |
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