Protective effects of 3, 4‐dihydroxybenzoic acid on myocardial infarction induced by isoproterenol in rats

Despite considerable advances in interventions and treatment, there is a high mortality rate in patients with myocardial infarction (MI). This is the first study to investigate the protective effects of 3, 4‐dihydroxybenzoic acid against isoproterenol induced MI in rats. MI was induced by isoprotere...

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Veröffentlicht in:	Journal of biochemical and molecular toxicology 2024-08, Vol.38 (8), p.e23773-n/a
Hauptverfasser:	Vincent, Sikha, Stanely, Shervin Prince, Ponnian, Stanely Mainzen Prince
Format:	Artikel
Sprache:	eng
Schlagworte:	3, 4‐dihydroxybenzoic acid Acids Animals antioxidant Body weight Catalase Creatine Creatine kinase Cytokines Dihydroxybenzoic acid Gentisates - metabolism Gentisates - pharmacology Heart Heart attacks Homocysteine Hydroxybenzoates - pharmacology Interleukin 6 Interleukins Isoproterenol Isoproterenol - toxicity Kinases Male Myocardial infarction Myocardial Infarction - chemically induced Myocardial Infarction - metabolism Myocardial Infarction - prevention & control Myocardium - metabolism Myocardium - pathology Oxidative stress Oxidative Stress - drug effects Rats Rats, Sprague-Dawley Reverse transcription Superoxide dismutase Thiobarbituric acid Troponin Troponin I - blood Troponin I - metabolism
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Zusammenfassung:	Despite considerable advances in interventions and treatment, there is a high mortality rate in patients with myocardial infarction (MI). This is the first study to investigate the protective effects of 3, 4‐dihydroxybenzoic acid against isoproterenol induced MI in rats. MI was induced by isoproterenol (100‐mg/kg body weight) in rats. Then, rats were treated with 3, 4‐dihydroxybenzoic acid (16‐mg/kg body weight) for 2 weeks. Serum creatine kinase‐MB, cardiac troponin‐T, cardiac troponin‐I, and heart thiobarbituric acid reactive substances were significantly (p
ISSN:	1095-6670 1099-0461 1099-0461
DOI:	10.1002/jbt.23773