Biomarkers in the prediction of complications in pregnancy after assisted reproductive technology

Objectives To compare the temporal changes in mean arterial pressure (MAP), uterine artery pulsatility index (UtA‐PI), placental growth factor (PlGF), and soluble fms‐like tyrosine kinase‐1 (sFlt‐1) across gestation between assisted reproductive technology (ART) pregnancies complicated with great obstetrical syndromes (GOS) or gestational diabetes (GDM) ± large‐for‐gestational‐age (LGA) fetus, and uncomplicated ART pregnancies. Methods This was a prospective longitudinal study of 143 women with singleton pregnancies who conceived through ART at the Department of Obstetrics and Gynecology, Prince of Wales Hospital, the Chinese University of Hong Kong, Hong Kong SAR between December 2017 and January 2020. The participants were followed up at 6–6+3, 11–13+6, 20–24+6, 30–34+6, and 35–37+6 weeks for the measurement of MAP, UtA‐PI, PlGF, and sFlt‐1. A linear mixed‐effects analysis was performed to compare the biomarkers in the GOS, GDM ± LGA, and uncomplicated groups across gestation. Results Thirty‐three (23.1%) and fifty‐five (31.5%) women were diagnosed with GOS and GDM ± LGA, respectively. The GOS group had higher estimated marginal mean log10 MAP mulitples of the median (MoM) across gestation, compared with the uncomplicated group (0.00771 vs −0.02022; P