Pioneering the Photoactive Relevance of Quinazolinone–Fullereropyrrolidine Nanohybrids To Address Chemotherapeutic Resistance in Cancer

This study investigates the impact of C70 and C60 fullerenes on quinazolinone, specifically in quinazolinone–fulleropyrrolidine nanohybrids. The nanohybrids Q 3 C 70 M and Q 3 C 60 M exhibit distinct spectral shifts and have significant photobiological antineoplastic properties. Q 3 C 60 M enhances apoptosis, while Q 3 C 70 M reduces Cyclin A levels and counteracts oncogenic effects by promoting cell differentiation. Q 3 C 70 M demonstrates heightened cytotoxicity by overcoming chemotherapy resistance by modulating BAX and BCL-2 levels. This innovative approach, distinguishing between C70 and C60, represents a novel contribution to the existing scientific literature.