A methodological pipeline for the preclinical evaluation of novel topical agents for the treatment of CRS

Key points Novel topical therapeutics require extensive pre‐clinical testing to assess efficacy and safety. Antibiofilm or immunosuppressant agents can utilize ex vivo models to measure ciliotoxicity. Agents that are found to be effective and non‐toxic ex vivo warrant further investigation in vivo....

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Veröffentlicht in:	International forum of allergy & rhinology 2024-11, Vol.14 (11), p.1818-1821
Hauptverfasser:	Hale, Samuel J. M., Lux, Christian A., Willoughby, James E., Koefoed, Arne, Broderick, David, Biswas, Kristi, Kim, Raymond, Mackenzie, Brett Wagner, Douglas, Richard G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Animals biofilm Biofilms - drug effects chronic rhinosinusitis ciliary motility Drug Evaluation, Preclinical - methods Humans Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - toxicity medical therapy of chronic rhinosinusitis therapeutics topical therapy for chronic rhinosinusitis
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Beschreibung
Zusammenfassung:	Key points Novel topical therapeutics require extensive pre‐clinical testing to assess efficacy and safety. Antibiofilm or immunosuppressant agents can utilize ex vivo models to measure ciliotoxicity. Agents that are found to be effective and non‐toxic ex vivo warrant further investigation in vivo.
ISSN:	2042-6976 2042-6984 2042-6984
DOI:	10.1002/alr.23418