Investigating the antimicrobial potential of bovine lactoferrin against the neonatal pathogen, Staphylococcus capitis
Lactoferrin is an antimicrobial glycoprotein that demonstrates a broad-spectrum of activity against a wide variety of clinical pathogens. This study investigated the potential of bovine lactoferrin (bLf) against multidrug resistant Staphylococcus capitis (S. capitis) strains. Growth curve analysis a...
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| Veröffentlicht in: | Letters in applied microbiology 2024-07, Vol.77 (7) |
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| container_title | Letters in applied microbiology |
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| creator | Desmond, Anna Cotter, Lesley Field, Des O'Halloran, Fiona |
| description | Lactoferrin is an antimicrobial glycoprotein that demonstrates a broad-spectrum of activity against a wide variety of clinical pathogens. This study investigated the potential of bovine lactoferrin (bLf) against multidrug resistant Staphylococcus capitis (S. capitis) strains. Growth curve analysis and time-kill curves demonstrated that at 750 µg ml-1 lactoferrin significantly inhibited (50.6%, P |
| doi_str_mv | 10.1093/lambio/ovae068 |
| format | Article |
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This study investigated the potential of bovine lactoferrin (bLf) against multidrug resistant Staphylococcus capitis (S. capitis) strains. Growth curve analysis and time-kill curves demonstrated that at 750 µg ml-1 lactoferrin significantly inhibited (50.6%, P < 0.05) the growth of most isolates tested (90%), and this effect was based on a bacteriostatic mechanism. At the same concentration, bLf also significantly inhibited (30%, P < 0.05) biofilm formation in 40% of strains tested. Combinations of bLf with selected antibiotics were assessed for enhanced antimicrobial activity using growth curves. BLf combined with β-lactam antibiotics reduced the growth of S. capitis strains, however, the effects were not significant. BLf displays antimicrobial effects against multidrug resistant S. capitis isolates, but with strain-specific effects.</description><identifier>ISSN: 1472-765X</identifier><identifier>EISSN: 1472-765X</identifier><identifier>DOI: 10.1093/lambio/ovae068</identifier><identifier>PMID: 39009015</identifier><language>eng</language><publisher>England</publisher><subject>Animals ; Anti-Bacterial Agents - pharmacology ; Biofilms - drug effects ; Biofilms - growth & development ; Cattle ; Drug Resistance, Multiple, Bacterial ; Lactoferrin - pharmacology ; Microbial Sensitivity Tests ; Staphylococcal Infections - microbiology ; Staphylococcus capitis - drug effects</subject><ispartof>Letters in applied microbiology, 2024-07, Vol.77 (7)</ispartof><rights>The Author(s) 2024. 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This study investigated the potential of bovine lactoferrin (bLf) against multidrug resistant Staphylococcus capitis (S. capitis) strains. Growth curve analysis and time-kill curves demonstrated that at 750 µg ml-1 lactoferrin significantly inhibited (50.6%, P < 0.05) the growth of most isolates tested (90%), and this effect was based on a bacteriostatic mechanism. At the same concentration, bLf also significantly inhibited (30%, P < 0.05) biofilm formation in 40% of strains tested. Combinations of bLf with selected antibiotics were assessed for enhanced antimicrobial activity using growth curves. BLf combined with β-lactam antibiotics reduced the growth of S. capitis strains, however, the effects were not significant. BLf displays antimicrobial effects against multidrug resistant S. capitis isolates, but with strain-specific effects.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Biofilms - drug effects</subject><subject>Biofilms - growth & development</subject><subject>Cattle</subject><subject>Drug Resistance, Multiple, Bacterial</subject><subject>Lactoferrin - pharmacology</subject><subject>Microbial Sensitivity Tests</subject><subject>Staphylococcal Infections - microbiology</subject><subject>Staphylococcus capitis - drug effects</subject><issn>1472-765X</issn><issn>1472-765X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkEtLAzEUhYMotla3LiVLF7ZNMo_MLEV8FAouVHA33KTJNDKTjJNMof_e9KG4uofLOZd7PoSuKZlRUibzBlph3NxtQJG8OEFjmnI25Xn2efpPj9CF91-EkIKy8hyNkpKQktBsjIaF3SgfTA3B2BqHtcJgg2mN7J0w0ODOBRUXUTmNhdsYq3ADMjit-t5YDDUY68M-aZWzEHYhCGtXK3uH3wJ0623jpJNy8FhCZ4Lxl-hMQ-PV1XFO0MfT4_vDy3T5-rx4uF9OJWMkTAtR6jTjGRWMi9hPZDLVhWYlp1pSwtJYQQu6yrlclUWecMa1UrLIRZoJmqXJBN0e7na9-x5iz6o1Xqqmgfjq4KtkD4QyxqN1drDG4t73Slddb1rotxUl1Q51dUBdHVHHwM3x9iBatfqz_7JNfgC_a3-F</recordid><startdate>20240701</startdate><enddate>20240701</enddate><creator>Desmond, Anna</creator><creator>Cotter, Lesley</creator><creator>Field, Des</creator><creator>O'Halloran, Fiona</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20240701</creationdate><title>Investigating the antimicrobial potential of bovine lactoferrin against the neonatal pathogen, Staphylococcus capitis</title><author>Desmond, Anna ; Cotter, Lesley ; Field, Des ; O'Halloran, Fiona</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c220t-8b9f45751b27be06b5c4f8f2971fc1024015fb1d67cd9863727feec86b45b1543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Biofilms - drug effects</topic><topic>Biofilms - growth & development</topic><topic>Cattle</topic><topic>Drug Resistance, Multiple, Bacterial</topic><topic>Lactoferrin - pharmacology</topic><topic>Microbial Sensitivity Tests</topic><topic>Staphylococcal Infections - microbiology</topic><topic>Staphylococcus capitis - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Desmond, Anna</creatorcontrib><creatorcontrib>Cotter, Lesley</creatorcontrib><creatorcontrib>Field, Des</creatorcontrib><creatorcontrib>O'Halloran, Fiona</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Letters in applied microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Desmond, Anna</au><au>Cotter, Lesley</au><au>Field, Des</au><au>O'Halloran, Fiona</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigating the antimicrobial potential of bovine lactoferrin against the neonatal pathogen, Staphylococcus capitis</atitle><jtitle>Letters in applied microbiology</jtitle><addtitle>Lett Appl Microbiol</addtitle><date>2024-07-01</date><risdate>2024</risdate><volume>77</volume><issue>7</issue><issn>1472-765X</issn><eissn>1472-765X</eissn><abstract>Lactoferrin is an antimicrobial glycoprotein that demonstrates a broad-spectrum of activity against a wide variety of clinical pathogens. This study investigated the potential of bovine lactoferrin (bLf) against multidrug resistant Staphylococcus capitis (S. capitis) strains. Growth curve analysis and time-kill curves demonstrated that at 750 µg ml-1 lactoferrin significantly inhibited (50.6%, P < 0.05) the growth of most isolates tested (90%), and this effect was based on a bacteriostatic mechanism. At the same concentration, bLf also significantly inhibited (30%, P < 0.05) biofilm formation in 40% of strains tested. Combinations of bLf with selected antibiotics were assessed for enhanced antimicrobial activity using growth curves. BLf combined with β-lactam antibiotics reduced the growth of S. capitis strains, however, the effects were not significant. BLf displays antimicrobial effects against multidrug resistant S. capitis isolates, but with strain-specific effects.</abstract><cop>England</cop><pmid>39009015</pmid><doi>10.1093/lambio/ovae068</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | Letters in applied microbiology, 2024-07, Vol.77 (7) |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Animals Anti-Bacterial Agents - pharmacology Biofilms - drug effects Biofilms - growth & development Cattle Drug Resistance, Multiple, Bacterial Lactoferrin - pharmacology Microbial Sensitivity Tests Staphylococcal Infections - microbiology Staphylococcus capitis - drug effects |
| title | Investigating the antimicrobial potential of bovine lactoferrin against the neonatal pathogen, Staphylococcus capitis |
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