Investigating the antimicrobial potential of bovine lactoferrin against the neonatal pathogen, Staphylococcus capitis

Lactoferrin is an antimicrobial glycoprotein that demonstrates a broad-spectrum of activity against a wide variety of clinical pathogens. This study investigated the potential of bovine lactoferrin (bLf) against multidrug resistant Staphylococcus capitis (S. capitis) strains. Growth curve analysis a...

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Veröffentlicht in:	Letters in applied microbiology 2024-07, Vol.77 (7)
Hauptverfasser:	Desmond, Anna, Cotter, Lesley, Field, Des, O'Halloran, Fiona
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Biofilms - drug effects Biofilms - growth & development Cattle Drug Resistance, Multiple, Bacterial Lactoferrin - pharmacology Microbial Sensitivity Tests Staphylococcal Infections - microbiology Staphylococcus capitis - drug effects
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Zusammenfassung:	Lactoferrin is an antimicrobial glycoprotein that demonstrates a broad-spectrum of activity against a wide variety of clinical pathogens. This study investigated the potential of bovine lactoferrin (bLf) against multidrug resistant Staphylococcus capitis (S. capitis) strains. Growth curve analysis and time-kill curves demonstrated that at 750 µg ml-1 lactoferrin significantly inhibited (50.6%, P
ISSN:	1472-765X 1472-765X
DOI:	10.1093/lambio/ovae068