The effects of different types of social interactions on the electrophysiology of neurons in the nucleus accumbens in rodents

BORLAND, J.M., The effects of different types of social interactions on the electrophysiology of neurons in the nucleus accumbens in rodents, NEUROSCI BIOBEH REV 21(1) XXX-XXX, 2024.-Sociality shapes an organisms’ life. The nucleus accumbens is a critical brain region for mental health. In the following review, the effects of different types of social interactions on the physiology of neurons in the nucleus accumbens is synthesized. More specifically, the effects of sex behavior, aggression, social defeat, pair-bonding, play behavior, affiliative interactions, parental behaviors, the isolation from social interactions and maternal separation on measures of excitatory synaptic transmission, intracellular signaling and factors of transcription and translation in neurons in the nucleus accumbens in rodent models are reviewed. Similarities and differences in effects depending on the type of social interaction is then discussed. This review improves the understanding of the molecular and synaptic mechanisms of sociality. •Social behaviors change intracellular signaling pathways and synaptic plasticity.•Sex behavior, aggression and social defeat, but not pair-bonding, increase DeltaFosB.•Unlike sex and aggression, pair-bonding decreases signaling of NAc neurons.•Social defeat cell-type effects (D1/D2-MSNs) opposite of sex and aggression.•Sex and aggression differ in synaptic morphology.