The Tri-Steps Model of Critical Conditions in Intensive Care: Introducing a New Paradigm for Chronic Critical Illness

The Tri-Steps Model of Critical Conditions in Intensive Care: Introducing a New Paradigm for Chronic Critical Illness

The prevailing model for understanding chronic critical illness is a biphasic model, suggesting phases of acute and chronic critical conditions. A major challenge within this model is the difficulty in determining the timing of the process chronicity. It is likely that the triad of symptoms (inflamm...

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Veröffentlicht in:Journal of clinical medicine 2024-06, Vol.13 (13), p.3683
Hauptverfasser: Likhvantsev, Valery V, Berikashvili, Levan B, Yadgarov, Mikhail Ya, Yakovlev, Alexey A, Kuzovlev, Artem N
Format: Artikel
Sprache:eng
Schlagworte:
Collaboration
Epidemiology
Etiology
Hospitalization
Hospitals
Illnesses
Inflammation
Intensive care
Lymphocytes
Medical prognosis
Mortality
Patients
Regression analysis
Variables
Ventilators
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Zusammenfassung:The prevailing model for understanding chronic critical illness is a biphasic model, suggesting phases of acute and chronic critical conditions. A major challenge within this model is the difficulty in determining the timing of the process chronicity. It is likely that the triad of symptoms (inflammation, catabolism, and immunosuppression [ICIS]) could be associated with this particular point. We aimed to explore the impact of the symptom triad (inflammation, catabolism, immunosuppression) on the outcomes of patients hospitalized in intensive care units (ICUs). The eICU-CRD database with 200,859 ICU admissions was analyzed. Adult patients with the ICIS triad, identified by elevated CRP (>20 mg/L), reduced albumin (
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm13133683