GeneMAP enables discovery of metabolic gene function

GeneMAP enables discovery of metabolic gene function

Identifying substrates of metabolic gene products is important to understand their function in physiology and disease. We developed GeneMAP, a multiomics platform for predicting metabolic gene functions using models of gene expression. We experimentally validated a top-scoring gene–metabolite associ...

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Veröffentlicht in:Nature genetics 2024-08, Vol.56 (8), p.1552-1553
Hauptverfasser: Khan, Artem, Birsoy, Kıvanç
Format: Artikel
Sprache:eng
Schlagworte:
631/114/2785
631/45/320
Agriculture
Animal Genetics and Genomics
Biomedical and Life Sciences
Biomedicine
Cancer Research
Disease
Enzymes
Gene expression
Gene Function
Genetic diversity
Genetic variance
Genetics
Genome-wide association studies
Genomics
Homeostasis
Human Genetics
Metabolism
Metabolites
Physiology
Protein transport
Protein turnover
Proteins
Research Briefing
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Beschreibung
Zusammenfassung:Identifying substrates of metabolic gene products is important to understand their function in physiology and disease. We developed GeneMAP, a multiomics platform for predicting metabolic gene functions using models of gene expression. We experimentally validated a top-scoring gene–metabolite association, thereby revealing a role for SLC25A48 in mitochondrial choline import.
ISSN:1061-4036
1546-1718
1546-1718
DOI:10.1038/s41588-024-01828-1