Organocatalytic Dearomatization of 5‑Aminopyrazoles: Synthesis of 4‑Hydroxypyrazolines
Dearomatization is a fundamental chemical reaction that affords complex three-dimensional heterocyclic frameworks. We disclose the first organocatalytic dearomatization of 5-aminopyrazoles, which yields a range of structurally diversified C4-hydroxylated pyrazolines with yields of ≤95% in
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| Veröffentlicht in: | Journal of organic chemistry 2024-07, Vol.89 (14), p.10258-10271 |
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| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Dearomatization is a fundamental chemical reaction that affords complex three-dimensional heterocyclic frameworks. We disclose the first organocatalytic dearomatization of 5-aminopyrazoles, which yields a range of structurally diversified C4-hydroxylated pyrazolines with yields of ≤95% in |
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| ISSN: | 0022-3263 1520-6904 1520-6904 |
| DOI: | 10.1021/acs.joc.4c01160 |