Calcitonin Gene-Related Peptide Inhibition and Development of Acne and Rosacea

Calcitonin gene-related peptide (CGRP) is a neuropeptide that triggers vasodilation and inflammation. CGRP signaling has been implicated in migraine and rosacea pathogenesis. CGRP inhibitor (CGRPi) monoclonal antibodies (mAbs) and nonpeptide small molecules (gepants) are effective for migraine treatment, and patients with migraines and rosacea have experienced improvement in rosacea symptoms after receiving CGRPimAbs. CGRP may also be involved in acne pathogenesis because its receptor is expressed in sebaceous glands, and CGRP signaling mediates inflammation triggered by Cutibacterium acnes.