Enhancement on CT for preoperative diagnosis of metastatic lymph nodes in thyroid cancer: a comparison across experience levels

Objectives To investigate the diagnostic performance and interobserver agreement of quantitative CT parameters indicating strong lymph node (LN) enhancement in differentiated thyroid cancer (DTC), comparing them with qualitative analysis by radiologists of varying experience. Materials and methods This study included 463 LNs from 399 patients with DTC. Three radiologists independently analyzed strong LN enhancement on CT. Qualitative analysis of strong enhancement was defined as LN cortex showing greater enhancement than adjacent muscles on the arterial phase. Quantitative analysis included the mean attenuation value (MAV) of LN on arterial phase (LN A ) and venous phase (LN V ), LN A normalized to the common carotid artery (NAV CCA ), internal jugular vein (NAV IJV ), and sternocleidomastoid muscle (NAV SCM ), attenuation difference [AD; (LN A − MAV SCM )], and relative washout ratio [((LN A − LN V )/LN A ) × 100]. The interobserver agreement and diagnostic performance of the quantitative and qualitative analyses were evaluated. Results Interobserver agreement was excellent for all quantitative CT parameters (ICC, 0.83–0.94) and substantial for qualitative assessment (κ = 0.61). All CT parameters except for LN V showed good diagnostic performance for metastatic LNs (AUC, 0.81–0.85). NAV CCA (0.85, 95% CI: 0.8–0.9) and AD (0.85, 95% CI: 0.81–0.89) had the highest AUCs. All quantitative parameters except for NAV IJV had significantly higher AUCs than qualitative assessments by inexperienced radiologists, with no significant difference from assessments by an experienced radiologist. Conclusion Quantitative assessment of LN enhancement on arterial phase CT showed higher interobserver agreement and AUC values than qualitative analysis by inexperienced radiologists, supporting the need for a standardized quantitative CT parameter-based model for determining strong LN enhancement. Clinical relevance statement When assessing strong LN enhancement in DTC, quantitative CT parameters indicating strong enhancement can improve interobserver agreement, regardless of experience level. Therefore, the development of a standardized diagnostic model based on quantitative CT parameters might be necessary. Key Points Accurate preoperative assessment of LN metastasis in thyroid cancer is crucial . Quantitative CT parameters indicating strong LN enhancement demonstrated excellent interobserver agreement and good diagnostic performance . Quantitative assessment of contrast enh