The mlpt smORF gene is essential for digestive physiology and molting during nymphal stages in the kissing bug Rhodnius prolixus

Chagas disease affects around 8 million people globally, with Latin America bearing approximately 10,000 deaths each year. Combatting the disease relies heavily on vector control methods, necessitating the identification of new targets. Within insect genomes, genes harboring small open reading frame...

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Veröffentlicht in:	Insect biochemistry and molecular biology 2024-09, Vol.172, p.104154, Article 104154
Hauptverfasser:	Silva, Carina Azevedo Oliveira, Alves, Sandy da Silveira, Rodrigues, Bruno da Costa, Fraga Egidio, Jonatha Anderson, Ribeiro, Lupis, Logullo, Carlos, Mury, Flavia Borges, Santos, Daniele das Graças, Portal, Taynan, Monteiro-de-Barros, Cintia, Roberto da Silva, José, Nepomuceno-Silva, José Luciano, Nunes-da-Fonseca, Rodrigo
Format:	Artikel
Sprache:	eng
Schlagworte:	American trypanosomiasis Animals Chagas disease Digestion digestive physiology disease transmission double-stranded RNA Ecdysone etiological agents genes glucose Hemozoin hindgut histology hormonal regulation insect biochemistry Insect development Insect Proteins - genetics Insect Proteins - metabolism insects juvenile hormones Juvenile Hormones - metabolism Latin America midgut molecular biology Molting - genetics Nymph - genetics Nymph - growth & development Nymph - physiology Open Reading Frames parasites Polished-rice/tarsalless Rhodnius - genetics Rhodnius - growth & development Rhodnius - physiology Rhodnius prolixus transcription factors Trypanosoma cruzi vector control
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Zusammenfassung:	Chagas disease affects around 8 million people globally, with Latin America bearing approximately 10,000 deaths each year. Combatting the disease relies heavily on vector control methods, necessitating the identification of new targets. Within insect genomes, genes harboring small open reading frames (smORFs -
ISSN:	0965-1748 1879-0240 1879-0240
DOI:	10.1016/j.ibmb.2024.104154