Multiple small‐dose infusions of G‐CSF‐mobilized haploidentical lymphocytes after autologous haematopoietic stem cell transplantation for acute myeloid leukaemia
Summary This retrospective study analysed 106 acute myeloid leukaemia (AML) patients undergoing autologous haematopoietic stem cell transplantation (ASCT) to assess the impact of multiple small‐dose infusions of granulocyte‐colony‐stimulating factor (G‐CSF)‐mobilized haploidentical lymphocytes as po...
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| Veröffentlicht in: | British journal of haematology 2024-08, Vol.205 (2), p.645-652 |
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| creator | Yang, Fei Ren, Quan Zu, Yingling Gui, Ruirui Li, Zhen Wang, Juan Zhang, Yanli Yu, Fengkuan Fang, Baijun Fu, Yuewen Wang, Yongliang Liu, Yanyan Zhang, Lina Zuo, Wenli Li, Yufu Lin, Quande Zhao, Huifang Wang, Ping Zhang, Binglei Huang, Zhenghua Song, Yongping Zhou, Jian |
| description | Summary
This retrospective study analysed 106 acute myeloid leukaemia (AML) patients undergoing autologous haematopoietic stem cell transplantation (ASCT) to assess the impact of multiple small‐dose infusions of granulocyte‐colony‐stimulating factor (G‐CSF)‐mobilized haploidentical lymphocytes as post‐ASCT maintenance therapy. Among them, 50 patients received lymphocyte maintenance therapy, 21 received alternative maintenance therapy, and 35 received no maintenance therapy. Patients receiving lymphocyte maintenance therapy demonstrated significantly higher overall survival (OS) and disease‐free survival (DFS) compared to those without maintenance therapy, with 4‐year OS and DFS rates notably elevated. While there were no significant differences in recurrence rates among the three groups, lymphocyte maintenance therapy showcased particular benefits for intermediate‐risk AML patients, yielding significantly higher OS and DFS rates and lower relapse rates compared to alternative maintenance therapy and no maintenance therapy. The study suggests that multiple small‐dose infusions of G‐CSF‐mobilized haploidentical lymphocytes may offer promising outcomes for AML patients after ASCT, particularly for those classified as intermediate‐risk. These findings underscore the potential efficacy of lymphocyte maintenance therapy in reducing disease relapse and improving long‐term prognosis in this patient population.
Lymphocyte maintenance therapy has potential in reducing disease relapse and improving long‐term prognosis in patients with acute myeloid leukaemia undergoing autologous haematopoietic stem cell transplantation. |
| doi_str_mv | 10.1111/bjh.19597 |
| format | Article |
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This retrospective study analysed 106 acute myeloid leukaemia (AML) patients undergoing autologous haematopoietic stem cell transplantation (ASCT) to assess the impact of multiple small‐dose infusions of granulocyte‐colony‐stimulating factor (G‐CSF)‐mobilized haploidentical lymphocytes as post‐ASCT maintenance therapy. Among them, 50 patients received lymphocyte maintenance therapy, 21 received alternative maintenance therapy, and 35 received no maintenance therapy. Patients receiving lymphocyte maintenance therapy demonstrated significantly higher overall survival (OS) and disease‐free survival (DFS) compared to those without maintenance therapy, with 4‐year OS and DFS rates notably elevated. While there were no significant differences in recurrence rates among the three groups, lymphocyte maintenance therapy showcased particular benefits for intermediate‐risk AML patients, yielding significantly higher OS and DFS rates and lower relapse rates compared to alternative maintenance therapy and no maintenance therapy. The study suggests that multiple small‐dose infusions of G‐CSF‐mobilized haploidentical lymphocytes may offer promising outcomes for AML patients after ASCT, particularly for those classified as intermediate‐risk. These findings underscore the potential efficacy of lymphocyte maintenance therapy in reducing disease relapse and improving long‐term prognosis in this patient population.
Lymphocyte maintenance therapy has potential in reducing disease relapse and improving long‐term prognosis in patients with acute myeloid leukaemia undergoing autologous haematopoietic stem cell transplantation.</description><identifier>ISSN: 0007-1048</identifier><identifier>ISSN: 1365-2141</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1111/bjh.19597</identifier><identifier>PMID: 38972835</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>acute myeloid leukaemia ; Acute myeloid leukemia ; Adolescent ; Adult ; Aged ; Autografts ; Female ; Granulocyte Colony-Stimulating Factor - administration & dosage ; granulocyte colony‐stimulating factor ; haematopoietic stem cell transplantation ; Hematopoietic Stem Cell Mobilization - methods ; Hematopoietic Stem Cell Transplantation - methods ; Hematopoietic stem cells ; Humans ; Leukemia ; Leukemia, Myeloid, Acute - therapy ; Leukocytes (granulocytic) ; Lymphocyte Transfusion ; Lymphocytes ; Male ; Medical prognosis ; Middle Aged ; relapse prevention ; Retrospective Studies ; Stem cell transplantation ; Transplantation, Autologous ; Transplantation, Haploidentical - methods ; Young Adult</subject><ispartof>British journal of haematology, 2024-08, Vol.205 (2), p.645-652</ispartof><rights>2024 British Society for Haematology and John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2437-1a5a36da2343790d07aa721c905af2c77d831a0b4ee5d5a3ee5aa1bbf39881173</cites><orcidid>0000-0002-4615-7586 ; 0000-0001-8290-3104 ; 0000-0003-0083-6011 ; 0000-0002-2981-5487 ; 0000-0001-5537-0357 ; 0000-0001-7268-4809</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fbjh.19597$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fbjh.19597$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38972835$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Fei</creatorcontrib><creatorcontrib>Ren, Quan</creatorcontrib><creatorcontrib>Zu, Yingling</creatorcontrib><creatorcontrib>Gui, Ruirui</creatorcontrib><creatorcontrib>Li, Zhen</creatorcontrib><creatorcontrib>Wang, Juan</creatorcontrib><creatorcontrib>Zhang, Yanli</creatorcontrib><creatorcontrib>Yu, Fengkuan</creatorcontrib><creatorcontrib>Fang, Baijun</creatorcontrib><creatorcontrib>Fu, Yuewen</creatorcontrib><creatorcontrib>Wang, Yongliang</creatorcontrib><creatorcontrib>Liu, Yanyan</creatorcontrib><creatorcontrib>Zhang, Lina</creatorcontrib><creatorcontrib>Zuo, Wenli</creatorcontrib><creatorcontrib>Li, Yufu</creatorcontrib><creatorcontrib>Lin, Quande</creatorcontrib><creatorcontrib>Zhao, Huifang</creatorcontrib><creatorcontrib>Wang, Ping</creatorcontrib><creatorcontrib>Zhang, Binglei</creatorcontrib><creatorcontrib>Huang, Zhenghua</creatorcontrib><creatorcontrib>Song, Yongping</creatorcontrib><creatorcontrib>Zhou, Jian</creatorcontrib><title>Multiple small‐dose infusions of G‐CSF‐mobilized haploidentical lymphocytes after autologous haematopoietic stem cell transplantation for acute myeloid leukaemia</title><title>British journal of haematology</title><addtitle>Br J Haematol</addtitle><description>Summary
This retrospective study analysed 106 acute myeloid leukaemia (AML) patients undergoing autologous haematopoietic stem cell transplantation (ASCT) to assess the impact of multiple small‐dose infusions of granulocyte‐colony‐stimulating factor (G‐CSF)‐mobilized haploidentical lymphocytes as post‐ASCT maintenance therapy. Among them, 50 patients received lymphocyte maintenance therapy, 21 received alternative maintenance therapy, and 35 received no maintenance therapy. Patients receiving lymphocyte maintenance therapy demonstrated significantly higher overall survival (OS) and disease‐free survival (DFS) compared to those without maintenance therapy, with 4‐year OS and DFS rates notably elevated. While there were no significant differences in recurrence rates among the three groups, lymphocyte maintenance therapy showcased particular benefits for intermediate‐risk AML patients, yielding significantly higher OS and DFS rates and lower relapse rates compared to alternative maintenance therapy and no maintenance therapy. The study suggests that multiple small‐dose infusions of G‐CSF‐mobilized haploidentical lymphocytes may offer promising outcomes for AML patients after ASCT, particularly for those classified as intermediate‐risk. These findings underscore the potential efficacy of lymphocyte maintenance therapy in reducing disease relapse and improving long‐term prognosis in this patient population.
Lymphocyte maintenance therapy has potential in reducing disease relapse and improving long‐term prognosis in patients with acute myeloid leukaemia undergoing autologous haematopoietic stem cell transplantation.</description><subject>acute myeloid leukaemia</subject><subject>Acute myeloid leukemia</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Autografts</subject><subject>Female</subject><subject>Granulocyte Colony-Stimulating Factor - administration & dosage</subject><subject>granulocyte colony‐stimulating factor</subject><subject>haematopoietic stem cell transplantation</subject><subject>Hematopoietic Stem Cell Mobilization - methods</subject><subject>Hematopoietic Stem Cell Transplantation - methods</subject><subject>Hematopoietic stem cells</subject><subject>Humans</subject><subject>Leukemia</subject><subject>Leukemia, Myeloid, Acute - therapy</subject><subject>Leukocytes (granulocytic)</subject><subject>Lymphocyte Transfusion</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Middle Aged</subject><subject>relapse prevention</subject><subject>Retrospective Studies</subject><subject>Stem cell transplantation</subject><subject>Transplantation, Autologous</subject><subject>Transplantation, Haploidentical - methods</subject><subject>Young Adult</subject><issn>0007-1048</issn><issn>1365-2141</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcFu1DAQhi1ERZfCgRdAlrjAYVs7TuLkSFe0pSriAJyjSTJhvdhxiG2hcOIReAveiydhtttyQGIOM7L1zT8z-hl7JsWppDhrd9tTWRe1fsBWUpXFOpO5fMhWQgi9liKvjtnjEHZCSCUK-Ygdq6rWWaWKFfv1LtloJos8OLD294-fvQ_IzTikYPwYuB_4Jf1uPlxQdr411nzHnm9hst70OEbTgeV2cdPWd0vEwGGIOHNI0Vv_2adALDqIfvIGieYhouMdWsvjDGOYLIwRIg3jg6e-LkXkbsG9PLeYvlC3gSfsaAAb8OldPWGfLt583Fytb95fvt28vll3Wa7oWChAlT1kil616IUG0JnsalHAkHVa95WSINocsegJpQIg23ZQdVVJqdUJe3nQnWb_NWGIjTNhvyyMSLc0SuhSl6qsS0Jf_IPufJpH2o6oWuhKi1wQ9epAdbMPYcahmWbjYF4aKZq9ew2519y6R-zzO8XUOuz_kvd2EXB2AL4Zi8v_lZrz66uD5B_ycqrl</recordid><startdate>202408</startdate><enddate>202408</enddate><creator>Yang, Fei</creator><creator>Ren, Quan</creator><creator>Zu, Yingling</creator><creator>Gui, Ruirui</creator><creator>Li, Zhen</creator><creator>Wang, Juan</creator><creator>Zhang, Yanli</creator><creator>Yu, Fengkuan</creator><creator>Fang, Baijun</creator><creator>Fu, Yuewen</creator><creator>Wang, Yongliang</creator><creator>Liu, Yanyan</creator><creator>Zhang, Lina</creator><creator>Zuo, Wenli</creator><creator>Li, Yufu</creator><creator>Lin, Quande</creator><creator>Zhao, Huifang</creator><creator>Wang, Ping</creator><creator>Zhang, Binglei</creator><creator>Huang, Zhenghua</creator><creator>Song, Yongping</creator><creator>Zhou, Jian</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4615-7586</orcidid><orcidid>https://orcid.org/0000-0001-8290-3104</orcidid><orcidid>https://orcid.org/0000-0003-0083-6011</orcidid><orcidid>https://orcid.org/0000-0002-2981-5487</orcidid><orcidid>https://orcid.org/0000-0001-5537-0357</orcidid><orcidid>https://orcid.org/0000-0001-7268-4809</orcidid></search><sort><creationdate>202408</creationdate><title>Multiple small‐dose infusions of G‐CSF‐mobilized haploidentical lymphocytes after autologous haematopoietic stem cell transplantation for acute myeloid leukaemia</title><author>Yang, Fei ; Ren, Quan ; Zu, Yingling ; Gui, Ruirui ; Li, Zhen ; Wang, Juan ; Zhang, Yanli ; Yu, Fengkuan ; Fang, Baijun ; Fu, Yuewen ; Wang, Yongliang ; Liu, Yanyan ; Zhang, Lina ; Zuo, Wenli ; Li, Yufu ; Lin, Quande ; Zhao, Huifang ; Wang, Ping ; Zhang, Binglei ; Huang, Zhenghua ; Song, Yongping ; Zhou, Jian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2437-1a5a36da2343790d07aa721c905af2c77d831a0b4ee5d5a3ee5aa1bbf39881173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>acute myeloid leukaemia</topic><topic>Acute myeloid leukemia</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Autografts</topic><topic>Female</topic><topic>Granulocyte Colony-Stimulating Factor - administration & dosage</topic><topic>granulocyte colony‐stimulating factor</topic><topic>haematopoietic stem cell transplantation</topic><topic>Hematopoietic Stem Cell Mobilization - methods</topic><topic>Hematopoietic Stem Cell Transplantation - methods</topic><topic>Hematopoietic stem cells</topic><topic>Humans</topic><topic>Leukemia</topic><topic>Leukemia, Myeloid, Acute - therapy</topic><topic>Leukocytes (granulocytic)</topic><topic>Lymphocyte Transfusion</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Middle Aged</topic><topic>relapse prevention</topic><topic>Retrospective Studies</topic><topic>Stem cell transplantation</topic><topic>Transplantation, Autologous</topic><topic>Transplantation, Haploidentical - methods</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Fei</creatorcontrib><creatorcontrib>Ren, Quan</creatorcontrib><creatorcontrib>Zu, Yingling</creatorcontrib><creatorcontrib>Gui, Ruirui</creatorcontrib><creatorcontrib>Li, Zhen</creatorcontrib><creatorcontrib>Wang, Juan</creatorcontrib><creatorcontrib>Zhang, Yanli</creatorcontrib><creatorcontrib>Yu, Fengkuan</creatorcontrib><creatorcontrib>Fang, Baijun</creatorcontrib><creatorcontrib>Fu, Yuewen</creatorcontrib><creatorcontrib>Wang, Yongliang</creatorcontrib><creatorcontrib>Liu, Yanyan</creatorcontrib><creatorcontrib>Zhang, Lina</creatorcontrib><creatorcontrib>Zuo, Wenli</creatorcontrib><creatorcontrib>Li, Yufu</creatorcontrib><creatorcontrib>Lin, Quande</creatorcontrib><creatorcontrib>Zhao, Huifang</creatorcontrib><creatorcontrib>Wang, Ping</creatorcontrib><creatorcontrib>Zhang, Binglei</creatorcontrib><creatorcontrib>Huang, Zhenghua</creatorcontrib><creatorcontrib>Song, Yongping</creatorcontrib><creatorcontrib>Zhou, Jian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Fei</au><au>Ren, Quan</au><au>Zu, Yingling</au><au>Gui, Ruirui</au><au>Li, Zhen</au><au>Wang, Juan</au><au>Zhang, Yanli</au><au>Yu, Fengkuan</au><au>Fang, Baijun</au><au>Fu, Yuewen</au><au>Wang, Yongliang</au><au>Liu, Yanyan</au><au>Zhang, Lina</au><au>Zuo, Wenli</au><au>Li, Yufu</au><au>Lin, Quande</au><au>Zhao, Huifang</au><au>Wang, Ping</au><au>Zhang, Binglei</au><au>Huang, Zhenghua</au><au>Song, Yongping</au><au>Zhou, Jian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multiple small‐dose infusions of G‐CSF‐mobilized haploidentical lymphocytes after autologous haematopoietic stem cell transplantation for acute myeloid leukaemia</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>2024-08</date><risdate>2024</risdate><volume>205</volume><issue>2</issue><spage>645</spage><epage>652</epage><pages>645-652</pages><issn>0007-1048</issn><issn>1365-2141</issn><eissn>1365-2141</eissn><abstract>Summary
This retrospective study analysed 106 acute myeloid leukaemia (AML) patients undergoing autologous haematopoietic stem cell transplantation (ASCT) to assess the impact of multiple small‐dose infusions of granulocyte‐colony‐stimulating factor (G‐CSF)‐mobilized haploidentical lymphocytes as post‐ASCT maintenance therapy. Among them, 50 patients received lymphocyte maintenance therapy, 21 received alternative maintenance therapy, and 35 received no maintenance therapy. Patients receiving lymphocyte maintenance therapy demonstrated significantly higher overall survival (OS) and disease‐free survival (DFS) compared to those without maintenance therapy, with 4‐year OS and DFS rates notably elevated. While there were no significant differences in recurrence rates among the three groups, lymphocyte maintenance therapy showcased particular benefits for intermediate‐risk AML patients, yielding significantly higher OS and DFS rates and lower relapse rates compared to alternative maintenance therapy and no maintenance therapy. The study suggests that multiple small‐dose infusions of G‐CSF‐mobilized haploidentical lymphocytes may offer promising outcomes for AML patients after ASCT, particularly for those classified as intermediate‐risk. These findings underscore the potential efficacy of lymphocyte maintenance therapy in reducing disease relapse and improving long‐term prognosis in this patient population.
Lymphocyte maintenance therapy has potential in reducing disease relapse and improving long‐term prognosis in patients with acute myeloid leukaemia undergoing autologous haematopoietic stem cell transplantation.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>38972835</pmid><doi>10.1111/bjh.19597</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-4615-7586</orcidid><orcidid>https://orcid.org/0000-0001-8290-3104</orcidid><orcidid>https://orcid.org/0000-0003-0083-6011</orcidid><orcidid>https://orcid.org/0000-0002-2981-5487</orcidid><orcidid>https://orcid.org/0000-0001-5537-0357</orcidid><orcidid>https://orcid.org/0000-0001-7268-4809</orcidid></addata></record> |
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| subjects | acute myeloid leukaemia Acute myeloid leukemia Adolescent Adult Aged Autografts Female Granulocyte Colony-Stimulating Factor - administration & dosage granulocyte colony‐stimulating factor haematopoietic stem cell transplantation Hematopoietic Stem Cell Mobilization - methods Hematopoietic Stem Cell Transplantation - methods Hematopoietic stem cells Humans Leukemia Leukemia, Myeloid, Acute - therapy Leukocytes (granulocytic) Lymphocyte Transfusion Lymphocytes Male Medical prognosis Middle Aged relapse prevention Retrospective Studies Stem cell transplantation Transplantation, Autologous Transplantation, Haploidentical - methods Young Adult |
| title | Multiple small‐dose infusions of G‐CSF‐mobilized haploidentical lymphocytes after autologous haematopoietic stem cell transplantation for acute myeloid leukaemia |
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