Catalyst Editing via Post-Synthetic Functionalization by Phosphonium Generation and Anion Exchange for Nickel-Catalyzed Ethylene/Acrylate Copolymerization

Rapid, efficient development of homogeneous catalysts featuring desired performance is critical to numerous catalytic transformations but remains a key challenge. Typically, this task relies heavily on ligand design that is often based on trial and error. Herein, we demonstrate a “catalyst editing”...

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Veröffentlicht in:Journal of the American Chemical Society 2024-07, Vol.146 (28), p.18797-18803
Hauptverfasser: Ghana, Priyabrata, Xiong, Shuoyan, Tekpor, Adjeoda, Bailey, Brad C., Spinney, Heather A., Henderson, Briana S., Agapie, Theodor
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container_end_page 18803
container_issue 28
container_start_page 18797
container_title Journal of the American Chemical Society
container_volume 146
creator Ghana, Priyabrata
Xiong, Shuoyan
Tekpor, Adjeoda
Bailey, Brad C.
Spinney, Heather A.
Henderson, Briana S.
Agapie, Theodor
description Rapid, efficient development of homogeneous catalysts featuring desired performance is critical to numerous catalytic transformations but remains a key challenge. Typically, this task relies heavily on ligand design that is often based on trial and error. Herein, we demonstrate a “catalyst editing” strategy in Ni-catalyzed ethylene/acrylate copolymerization. Specifically, alkylation of a pendant phosphine followed by anion exchange provides a high yield strategy for a large number of cationic Ni phosphonium catalysts with varying electronic and steric profiles. These catalysts are highly active in ethylene/acrylate copolymerization, and their behaviors are correlated with the electrophile and the anion used in late-stage functionalization.
doi_str_mv 10.1021/jacs.4c03416
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subjects alkylation
anion exchange
catalysts
copolymerization
ethylene
Lewis acids
ligands
phosphine
title Catalyst Editing via Post-Synthetic Functionalization by Phosphonium Generation and Anion Exchange for Nickel-Catalyzed Ethylene/Acrylate Copolymerization
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