Angiopoietin-like growth factor-derived peptides as biological activators of adipose-derived mesenchymal stromal cells

Adipose-derived mesenchymal stromal cells (AD-MSCs) are an essential issue in modern medicine. Extensive preclinical and clinical studies have shown that mesenchymal stromal/stem cells, including AD-MSCs, have specific properties (ability to differentiate into other cells, recruitment to the site of...

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Veröffentlicht in:Biomedicine & pharmacotherapy 2024-08, Vol.177, p.117052, Article 117052
Hauptverfasser: Schumacher, Adriana, Mucha, Piotr, Puchalska, Izabela, Deptuła, Milena, Wardowska, Anna, Tymińska, Agata, Filipowicz, Natalia, Mieczkowska, Alina, Sachadyn, Paweł, Piotrowski, Arkadiusz, Pikuła, Michał, Cichorek, Miroslawa
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Sprache:eng
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Zusammenfassung:Adipose-derived mesenchymal stromal cells (AD-MSCs) are an essential issue in modern medicine. Extensive preclinical and clinical studies have shown that mesenchymal stromal/stem cells, including AD-MSCs, have specific properties (ability to differentiate into other cells, recruitment to the site of injury) of particular importance in the regenerative process. Ongoing research aims to elucidate factors supporting AD-MSC culture and differentiation in vitro. Angiopoietin-like proteins (ANGPTLs), known for their pleiotropic effects in lipid and glucose metabolism, may play a significant role in this context. Regeneration is a complex and dynamic process controlled by many factors. ANGPTL6 (Angiopoietin-related growth factor, AGF), among many activities modulated the biological activity of stem cells. This study examined the influence of synthesized AGF-derived peptides, designated as AGF9 and AGF27, on AD-MSCs. AGF9 and AGF27 enhanced the viability and migration of AD-MSCs and acted as a chemotactic factor for these cells. AGF9 stimulated chondrogenesis and lipid synthesis during AD-MSCs differentiation, influenced AD-MSCs cytokine secretion and modulated transcriptome for such basic cell activities as migration, transport of molecules, and apoptosis. The ability of AGF9 to modulate the biological activity of AD-MSCs warrants the consideration of this peptide a noteworthy therapeutic agent that deserves further investigation for applications in regenerative medicine. [Display omitted] •Angiopoietin-like growth factor-derived peptides modulate AD-MSCs activities.•AGF9 affects adipogenesis and differentiation into osteocytes (osteogenesis).•AGF9 stimulates the chondrogenesis process.•AD-MSCs transcriptomic response to AGF9 changes some related biological processes.•AGF9 peptide is a potential medicinal product for use in the regeneration process.
ISSN:0753-3322
1950-6007
1950-6007
DOI:10.1016/j.biopha.2024.117052