Stereochemical Assignment of the 36-Membered Macrolide Ring Portion of Poecillastrin C

Stereochemical Assignment of the 36-Membered Macrolide Ring Portion of Poecillastrin C

Absolute configuration at 12 stereocenters in the 36-membered macrocyclic ring portion of poecillastrin C (1) was disclosed by chemical degradation and NMR analyses of 1, chemical synthesis, and molecular modeling techniques.

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Veröffentlicht in:Organic letters 2024-06, Vol.26 (25), p.5290-5294
Hauptverfasser: Irie, Raku, Hitora, Yuki, Watanabe, Ryuichi, Clark, Hugh, Suyama, Yu, Sekiya, Shinji, Suzuki, Toshiyuki, Takada, Kentaro, Matsunaga, Shigeki, Hosokawa, Seijiro, Oikawa, Masato
Format: Artikel
Sprache:eng
Schlagworte:
chemical degradation
macrolides
stereochemistry
synthesis
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Beschreibung
Zusammenfassung:Absolute configuration at 12 stereocenters in the 36-membered macrocyclic ring portion of poecillastrin C (1) was disclosed by chemical degradation and NMR analyses of 1, chemical synthesis, and molecular modeling techniques.
ISSN:1523-7060
1523-7052
1523-7052
DOI:10.1021/acs.orglett.4c01632