Imaging and mechanisms of heart failure with preserved ejection fraction: a state-of-the-art review

Abstract Understanding of the pathophysiology of heart failure with preserved ejection fraction (HFpEF) has advanced rapidly over the past two decades. Currently, HFpEF is recognized as a heterogeneous syndrome, and there is a growing movement towards developing personalized treatments based on phen...

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Veröffentlicht in:European heart journal cardiovascular imaging 2024-10, Vol.25 (11), p.1475-1490
Hauptverfasser: Harada, Tomonari, Tada, Atsushi, Borlaug, Barry A
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract Understanding of the pathophysiology of heart failure with preserved ejection fraction (HFpEF) has advanced rapidly over the past two decades. Currently, HFpEF is recognized as a heterogeneous syndrome, and there is a growing movement towards developing personalized treatments based on phenotype-guided strategies. Left ventricular dysfunction is a fundamental pathophysiological abnormality in HFpEF; however, recent evidence also highlights significant roles for the atria, right ventricle, pericardium, and extracardiac contributors. Imaging plays a central role in characterizing these complex and highly integrated domains of pathophysiology. This review focuses on established evidence, recent insights, and the challenges that need to be addressed concerning the pathophysiology of HFpEF, with a focus on imaging-based evaluations and opportunities for further research. Graphical Abstract Graphical Abstract
ISSN:2047-2404
2047-2412
2047-2412
DOI:10.1093/ehjci/jeae152