Female sex and age-based advantage of simulated electric field in TMS to the prefrontal cortex in schizophrenia and mood disorders
•Electric field is generated on the cerebral cortex by TMS.•We examined individual MRI based electric field models for TMS of left DLPFC.•Simulated electric field showed no difference among patients and healthy controls.•Associations of simulated electric field strength were observed for gender and...
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Veröffentlicht in: | Psychiatry research. Neuroimaging 2024-08, Vol.342, p.111844, Article 111844 |
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Sprache: | eng |
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Zusammenfassung: | •Electric field is generated on the cerebral cortex by TMS.•We examined individual MRI based electric field models for TMS of left DLPFC.•Simulated electric field showed no difference among patients and healthy controls.•Associations of simulated electric field strength were observed for gender and age.•Gender and age could be considered as factors increasing clinical efficacy for TMS.
This study investigates computational models of electric field strength for transcranial magnetic stimulation (TMS) of the left dorsolateral prefrontal cortex (DLPFC) based on individual MRI data of patients with schizophrenia (SZ), major depressive disorder (MDD), bipolar disorder (BP), and healthy controls (HC). In addition, it explores the association of electric field intensities with age, gender and intracranial volume. The subjects were 23 SZ (12 male, mean age = 45.30), 24 MDD (16 male, mean age = 43.57), 23 BP (16 male, mean age = 39.29), 23 HC (13 male, mean age = 40.91). Based on individual MRI sequences, electric fields were computationally modeled by two independent investigators using SimNIBS ver. 2.1.1. There was no significant difference in electric field strength between the groups (HC vs SZ, HC vs MDD, HC vs BP, SZ vs MDD, SZ vs BP, MDD vs BP). Female subjects showed higher electric field intensities in widespread areas than males, and age was positively significantly associated with electric field strength in the left parahippocampal area as observed. Our results suggest differences in electric field strength of left DLPFC TMS for gender and age. It may open future avenues for individually modeling TMS based on structural MRI data. |
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ISSN: | 0925-4927 1872-7506 1872-7506 |
DOI: | 10.1016/j.pscychresns.2024.111844 |