Insights from HIV-1 vaccine and passive immunization efficacy trials

An effective HIV-1 vaccine is still not available, and most vaccine efficacy trials conducted over the years resulted in no significant overall protection. Here we highlight several insights gained from these trials as well as emerging questions that may be important for further guidance to advance...

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Veröffentlicht in:	Trends in molecular medicine 2024-10, Vol.30 (10), p.908-912
Hauptverfasser:	Ahmed, Shamim, Herschhorn, Alon
Format:	Artikel
Sprache:	eng
Schlagworte:	antibody-mediated cell cytotoxicity antibody-mediated protection broadly neutralizing antibodies HIV-1 vaccines vaccine efficacy trials
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	An effective HIV-1 vaccine is still not available, and most vaccine efficacy trials conducted over the years resulted in no significant overall protection. Here we highlight several insights gained from these trials as well as emerging questions that may be important for further guidance to advance current research directions. An effective HIV-1 vaccine is still not available, and most vaccine efficacy trials conducted over the years resulted in no significant overall protection. Here we highlight several insights gained from these trials as well as emerging questions that may be important for further guidance to advance current research directions.
ISSN:	1471-4914 1471-499X 1471-499X
DOI:	10.1016/j.molmed.2024.05.017