GSE1 promotes the proliferation and migration of lung adenocarcinoma cells by downregulating KLF6 expression

Lung cancer is one of the most prevalent human cancers with a high lethality rate worldwide. In this study, we demonstrated that GSE1 (genetic suppressor element 1) expression is aberrantly upregulated in lung adenocarcinoma and that GSE1 depletion inhibits the proliferation and migration of both A5...

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Veröffentlicht in:	Cell biology international 2024-10, Vol.48 (10), p.1490-1506
Hauptverfasser:	Meng, Ziyu, Yang, Yingqian, Li, Shupei, Huang, Liguo, Yao, Zhoujuan, Chen, Yixuan, Wang, Junkun, Shen, Yiru, Liang, Pingping, Zhang, Hui, Wang, Wenbin, Wang, Fengsong
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Adenocarcinoma Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - pathology Adenocarcinoma of Lung - genetics Adenocarcinoma of Lung - metabolism Adenocarcinoma of Lung - pathology Bioinformatics Cell Line, Tumor Cell migration Cell Movement - genetics Cell proliferation Cell Proliferation - genetics Down-regulation Down-Regulation - genetics Gene Expression Regulation, Neoplastic GSE1 HDAC1 Histone deacetylase Histone Deacetylase 1 - genetics Histone Deacetylase 1 - metabolism Humans Immunoprecipitation KLF6 Kruppel-Like Factor 6 - genetics Kruppel-Like Factor 6 - metabolism Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - metabolism Lethality lung adenocarcinoma Lung cancer Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Metastases oncogene Small cell lung carcinoma Transcriptomes Tumor suppressor genes
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Zusammenfassung:	Lung cancer is one of the most prevalent human cancers with a high lethality rate worldwide. In this study, we demonstrated that GSE1 (genetic suppressor element 1) expression is aberrantly upregulated in lung adenocarcinoma and that GSE1 depletion inhibits the proliferation and migration of both A549 and H1299 cells. Immunoprecipitation assays demonstrated that GSE1 interacts with histone deacetylase 1 (HDAC1) and other BRAF–HDAC complex (BHC) components in cells. The transcriptome of GSE1‐knockdown A549 cells indicated that 207 genes were upregulated and 159 were downregulated based on a p‐value
ISSN:	1065-6995 1095-8355 1095-8355
DOI:	10.1002/cbin.12208