Urinary eosinophil‐derived neurotoxin is associated with reduced lung function in pediatric asthma

Urinary eosinophil‐derived neurotoxin is associated with reduced lung function in pediatric asthma

Introduction Eosinophil‐derived neurotoxin (EDN) is a biomarker for eosinophilic activation. Urinary (u) EDN may allow non‐invasive monitoring of asthma, but clinical recommendations are lacking. We assessed the potential of uEDN as a marker of disease activity in pediatric asthma. Methods We assess...

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Veröffentlicht in:Pediatric allergy and immunology 2024-06, Vol.35 (6), p.e14172-n/a
Hauptverfasser: Omony, Jimmy, Thölken, Clemens, Salimi, Azam, Laubhahn, Kristina, Illi, Sabina, Weckmann, Markus, Grychtol, Ruth, Rabe, Klaus Friedrich, Thiele, Dominik, Foth, Svenja, Weber, Stefanie, Brinkmann, Folke, Kopp, Matthias Volkmar, Hansen, Gesine, Renz, Harald, Mutius, Erika, Schaub, Bianca, Skevaki, Chrysanthi
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Allergens
Asthma
Asthma - urine
Atopy
biomarker
Biomarkers
Biomarkers - urine
Cell activation
Child
Child, Preschool
children
Creatinine
Eosinophil-derived neurotoxin
Eosinophil-Derived Neurotoxin - urine
Eosinophils - immunology
Female
Humans
Immunoassay
Immunoglobulin E
Immunoglobulin E - blood
Leukocytes (eosinophilic)
Lung - pathology
Lung diseases
Male
Medical diagnosis
Parametric statistics
Pediatrics
Phenotypes
Phenotyping
preschool wheeze
Regression analysis
Respiratory function
Respiratory Function Tests
T2‐high phenotype
Urine
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Zusammenfassung:Introduction Eosinophil‐derived neurotoxin (EDN) is a biomarker for eosinophilic activation. Urinary (u) EDN may allow non‐invasive monitoring of asthma, but clinical recommendations are lacking. We assessed the potential of uEDN as a marker of disease activity in pediatric asthma. Methods We assessed urine samples of 371 children from the German ALLIANCE study cohort, from which we had: 169 preschool wheezers (
ISSN:0905-6157
1399-3038
1399-3038
DOI:10.1111/pai.14172