Tumour microenvironment characterisation to stratify patients for hyperthermic intraperitoneal chemotherapy in high-grade serous ovarian cancer (OVHIPEC-1)

Background Hyperthermic intraperitoneal chemotherapy (HIPEC) improves survival in patients with Stage III ovarian cancer following interval cytoreductive surgery (CRS). Optimising patient selection is essential to maximise treatment efficacy and avoid overtreatment. This study aimed to identify biom...

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Veröffentlicht in:	British journal of cancer 2024-08, Vol.131 (3), p.565-576
Hauptverfasser:	Aronson, S. Lot, Walker, Cédric, Thijssen, Bram, van de Vijver, Koen K., Horlings, Hugo M., Sanders, Joyce, Alkemade, Maartje, Koole, Simone N., Lopez-Yurda, Marta, Lok, Christianne A. R., Rottenberg, Sven, van Rheenen, Jacco, Sonke, Gabe S., van Driel, Willemien J., Kester, Lennart A., Hahn, Kerstin
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1517/1709 631/67/1857 692/4028/67/1517/1709 692/53/2423 Aged Biomarkers Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Biomarkers, Tumor - immunology Biomedical and Life Sciences Biomedicine Cancer Research Chemotherapy Cystadenocarcinoma, Serous - drug therapy Cystadenocarcinoma, Serous - pathology Cystadenocarcinoma, Serous - therapy Cytoreduction Surgical Procedures Drug Resistance Epidemiology Female Gene expression Humans Hyperthermic Intraperitoneal Chemotherapy Lymphocytes B Macrophages Macrophages - pathology Middle Aged Molecular Medicine Oncology Ovarian cancer Ovarian Neoplasms - drug therapy Ovarian Neoplasms - pathology Ovarian Neoplasms - therapy Patients Transcriptomes Tumor Microenvironment Tumors
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