Risk of Second Tumors and T-Cell Lymphoma after CAR T-Cell Therapy

Second tumors after CAR T-cell therapy are rare, and in one case of a secondary T-cell lymphoma, detailed analysis showed that the genetic construct that was used to make the CAR T cells was unrelated to the second tumor.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2024-06, Vol.390 (22), p.2047-2060
Hauptverfasser:	Hamilton, Mark P., Sugio, Takeshi, Noordenbos, Troy, Shi, Shuyu, Bulterys, Philip L., Liu, Chih Long, Kang, Xiaoman, Olsen, Mari N., Good, Zinaida, Dahiya, Saurabh, Frank, Matthew J., Sahaf, Bita, Mackall, Crystal L., Gratzinger, Dita, Diehn, Maximilian, Alizadeh, Ash A., Miklos, David B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged B-cell lymphoma Biological Products - therapeutic use Biopsy Bone marrow Cancer Cell therapy Chimeric antigen receptors Clonal Hematopoiesis Cloning Epstein-Barr virus Female Gene expression Genetics Hematology Hematopoietic stem cells Hemopoiesis Herpesvirus 4, Human - genetics Herpesvirus 4, Human - immunology Humans Immunoglobulins Immunotherapy, Adoptive - adverse effects Leukemia Lymphocytes Lymphocytes B Lymphocytes T Lymphoma Lymphoma, Large B-Cell, Diffuse - genetics Lymphoma, Large B-Cell, Diffuse - immunology Lymphoma, Large B-Cell, Diffuse - therapy Lymphoma, T-Cell - etiology Lymphoma, T-Cell - immunology Lymphoma, T-Cell - therapy Male Middle Aged Mutation Neoplasms, Second Primary - etiology Neoplasms, Second Primary - genetics Oncology Plasma Receptors, Chimeric Antigen - immunology Receptors, Chimeric Antigen - therapeutic use T-cell lymphoma Tomography Treatments in Oncology Tumors Vectors (Biology)
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Beschreibung
Zusammenfassung:	Second tumors after CAR T-cell therapy are rare, and in one case of a secondary T-cell lymphoma, detailed analysis showed that the genetic construct that was used to make the CAR T cells was unrelated to the second tumor.
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMoa2401361