Validation of a clinical breast cancer risk assessment tool combining a polygenic score for all ancestries with traditional risk factors

We previously described a combined risk score (CRS) that integrates a multiple-ancestry polygenic risk score (MA-PRS) with the Tyrer-Cuzick (TC) model to assess breast cancer (BC) risk. Here, we present a longitudinal validation of CRS in a real-world cohort. This study included 130,058 patients ref...

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Veröffentlicht in:Genetics in medicine 2024-07, Vol.26 (7), p.101128, Article 101128
Hauptverfasser: Mabey, Brent, Hughes, Elisha, Kucera, Matthew, Simmons, Timothy, Hullinger, Brooke, Pederson, Holly J., Yehia, Lamis, Eng, Charis, Garber, Judy, Gary, Monique, Gordon, Ora, Klemp, Jennifer R., Mukherjee, Semanti, Vijai, Joseph, Offit, Kenneth, Olopade, Olufunmilayo I., Pruthi, Sandhya, Kurian, Allison, Robson, Mark E., Whitworth, Pat W., Pal, Tuya, Ratzel, Sarah, Wagner, Susanne, Lanchbury, Jerry S., Taber, Katherine Johansen, Slavin, Thomas P., Gutin, Alexander
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Sprache:eng
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