Engineering Core/Ligands Interfacial Anchors of Nanoparticles for Efficiently Inhibiting Both Aβ and Amylin Fibrillization

Accurate construction of artificial nano‐chaperones' structure is crucial for precise regulation of protein conformational transformation, facilitating effective treatment of proteopathy. However, how the ligand‐anchors of nano‐chaperones affect the spatial conformational changes in proteins re...

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Veröffentlicht in:	Small (Weinheim an der Bergstrasse, Germany) Germany), 2024-10, Vol.20 (40), p.e2312046-n/a
Hauptverfasser:	Deng, Yuzhou, Gao, Guanbin, Yu, Liangchong, Zhang, Zijun, Zhang, Bin, Li, Hu, Zhang, Xinyu, Shen, Lei, Sun, Taolei
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes amylin Amyloid - chemistry Amyloid beta-Peptides - chemistry anchor structures Benzoic acid Bonding strength core/ligands interface Gold Gold - chemistry gold nano‐chaperones Humans Islet Amyloid Polypeptide - chemistry Ligands Metal Nanoparticles - chemistry Nanomaterials Nanoparticles Peptides Proteins β‐amyloid
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