MiT family translocation-associated renal cell carcinoma: A report of two cases in children

Renal cell carcinoma is uncommon in children and must be distinguished from the more common Wilms' tumor. Here, we present two cases of renal cell carcinoma in children both of whom presented with hematuria. Accurate diagnosis is essential in order to differentiate it from epithelial predominan...

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Veröffentlicht in:	Indian journal of pathology & microbiology 2024-04, Vol.67 (2), p.469-471
Hauptverfasser:	Mukherjee, Sriranjan, Basu, Keya, Basu, Kalyani S, Chatterjee, Uttara
Format:	Artikel
Sprache:	eng
Schlagworte:	Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics Carcinoma, Renal Cell - diagnosis Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - pathology Cell differentiation Child Child, Preschool Children Diagnosis Diagnosis, Differential Female Hematuria Hematuria - etiology Humans Immunohistochemistry Kidney Neoplasms - diagnosis Kidney Neoplasms - genetics Kidney Neoplasms - pathology Male Renal cell carcinoma Translocation Translocation, Genetic Tumors Wilms Tumor - diagnosis Wilms Tumor - pathology
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Beschreibung
Zusammenfassung:	Renal cell carcinoma is uncommon in children and must be distinguished from the more common Wilms' tumor. Here, we present two cases of renal cell carcinoma in children both of whom presented with hematuria. Accurate diagnosis is essential in order to differentiate it from epithelial predominant Wilms' tumor which has vastly different prognosis and treatment. Immunohistochemistry for TFE3 is useful in establishing the diagnosis.
ISSN:	0377-4929 0974-5130 0974-5130
DOI:	10.4103/ijpm.ijpm_385_22