Glycoprotein from Sargassum fusiforme exhibiting anti-inflammatory responses in vitro and in vivo via modulation of TLR4/MyD88 and NF-κB signaling

Glycoprotein from Sargassum fusiforme exhibiting anti-inflammatory responses in vitro and in vivo via modulation of TLR4/MyD88 and NF-κB signaling

This study focuses on the identification and characterization of a glycoprotein from Sargassum fusiforme (Harvey) Setchell (SFGP), as well as investigating its potential anti-inflammatory properties both in vitro and in vivo, along with the underlying mechanism. SDS-PAGE analysis revealed a prominen...

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Veröffentlicht in:International journal of biological macromolecules 2024-06, Vol.272 (Pt 1), p.132574, Article 132574
Hauptverfasser: Javed, Ahsan, Song, Bo-Rim, Lee, Chang Hyung, Alam, Md Badrul, Kim, Solomon L., Lee, Sang-Han
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - pharmacology
Carrageenan model
Cyclooxygenase 2 - metabolism
Cytokines - metabolism
Edible Seaweeds
Glycoprotein
Glycoproteins - chemistry
Glycoproteins - pharmacology
Lipopolysaccharides
Male
Mice
Myeloid Differentiation Factor 88 - metabolism
NF-kappa B - metabolism
Nitric Oxide Synthase Type II - metabolism
O-glycopeptide
RAW 264.7
RAW 264.7 Cells
Sargassum - chemistry
Sargassum fusiforme
Signal Transduction - drug effects
Toll-Like Receptor 4 - metabolism
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Zusammenfassung:This study focuses on the identification and characterization of a glycoprotein from Sargassum fusiforme (Harvey) Setchell (SFGP), as well as investigating its potential anti-inflammatory properties both in vitro and in vivo, along with the underlying mechanism. SDS-PAGE analysis revealed a prominent band with a molecular weight of
ISSN:0141-8130
1879-0003
1879-0003
DOI:10.1016/j.ijbiomac.2024.132574