Invasive infections caused by the recently described species Enterococcus innesii

E. innesii is a recently described Enterococcus species which may be difficult to differentiate from the more common E. casseliflavus . We present the first clinical report of invasive E. innesii infection, featuring two cases of biliary sepsis. Whole genome sequencing confirmed the taxonomic assignment and the presence of vanC-4 . Analysis of public genomes identified 13 deposited E. innesii and 13 deposited E. casselifalvus / E.gallinarum genomes which could be reassigned as E. innesii . Improved laboratory diagnosis of E. innesii is expected to generate additional data concerning its clinical relevance and support the future diagnosis and treatment of this uncommon pathogen.