In vitro effect of hyoscine‐N‐butyl bromide and diclofenac sodium in human tuba uterina
Introduction To investigate the in vitro effect of diclofenac on tubal smooth muscle as an alternative to hyoscine‐N‐butyl bromide, which is used for premedication before hysterosalpingography (HSG). Material and Methods Fallopian tubes were retrieved from seven healthy women after bilateral tubal l...
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Veröffentlicht in: | Basic & clinical pharmacology & toxicology 2024-08, Vol.135 (2), p.173-179 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Introduction
To investigate the in vitro effect of diclofenac on tubal smooth muscle as an alternative to hyoscine‐N‐butyl bromide, which is used for premedication before hysterosalpingography (HSG).
Material and Methods
Fallopian tubes were retrieved from seven healthy women after bilateral tubal ligation and in vitro contractility and histological studies were conducted using tissue bath and immunohistochemistry.
Results
Diclofenac sodium and hyoscine‐N‐butyl bromide did not significantly change the basal mean tension; however, they decreased the contractions induced by potassium chloride (KCl). The relaxant effect of diclofenac sodium and hyoscine‐N‐butyl bromide was not statistically significantly different. The presence of cyclooxygenase (COX)‐2 enzyme in the fallopian tube was demonstrated by immunohistochemical studies.
Conclusions
The in vitro relaxant effect of diclofenac sodium on the fallopian tube is similar to hyoscine‐N‐butyl bromide. Diclofenac may have the potential to be used as an alternative to hyoscine‐N‐butyl bromide in premedication in HSG. |
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ISSN: | 1742-7835 1742-7843 1742-7843 |
DOI: | 10.1111/bcpt.14038 |