Oral health status of Egyptian children with lysosomal storage diseases: An evaluation of dental indices, salivary cytokines level, and bacterial bioburden
Background Lysosomal storage diseases (LSDs), a group of inborn errors of metabolism, include various subtypes, for example, mucopolysaccharidosis (MPS) and Gaucher disease (GD). Besides the physical/mental disabilities, they suffer from several oral deteriorations. Aim To evaluate the oral health s...
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Veröffentlicht in: | International journal of paediatric dentistry 2025-01, Vol.35 (1), p.155-164 |
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Sprache: | eng |
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Zusammenfassung: | Background
Lysosomal storage diseases (LSDs), a group of inborn errors of metabolism, include various subtypes, for example, mucopolysaccharidosis (MPS) and Gaucher disease (GD). Besides the physical/mental disabilities, they suffer from several oral deteriorations.
Aim
To evaluate the oral health status of Egyptian children with LSD.
Design
Thirty LSD children and thirty non‐LSD children were enrolled for this study according to the inclusion and exclusion criteria. Dental indices were used to assess caries prevalence and periodontal status. Saliva samples were collected from all enrolled children to estimate interleukin 6 (IL‐6), tumor necrosis factor‐α (TNF‐α), and protein levels as well as Streptococcus mutans and Lactobacilli colony counts.
Results
Children with MPS and GD showed non‐significant differences in decayed, missing, or filled teeth (DMFT) scores (p = .115). Scores of dmft showed a significant increase in MPS, but not in GD children (p = .020, p = .127). Children with LSD showed significantly increased Modified Gingival Index (MGI), Plaque Index (PI), Oral Hygiene Index (OHI‐s) scores (p |
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ISSN: | 0960-7439 1365-263X |
DOI: | 10.1111/ipd.13216 |