Integrative modeling meets deep learning: Recent advances in modeling protein assemblies

Recent progress in protein structure prediction based on deep learning revolutionized the field of Structural Biology. Beyond single proteins, it also enabled high-throughput prediction of structures of protein–protein interactions. Despite the success in predicting complex structures, large macromo...

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Veröffentlicht in:Current opinion in structural biology 2024-08, Vol.87, p.102841, Article 102841
Hauptverfasser: Shor, Ben, Schneidman-Duhovny, Dina
Format: Artikel
Sprache:eng
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Zusammenfassung:Recent progress in protein structure prediction based on deep learning revolutionized the field of Structural Biology. Beyond single proteins, it also enabled high-throughput prediction of structures of protein–protein interactions. Despite the success in predicting complex structures, large macromolecular assemblies still require specialized approaches. Here we describe recent advances in modeling macromolecular assemblies using integrative and hierarchical approaches. We highlight applications that predict protein–protein interactions and challenges in modeling complexes based on the interaction networks, including the prediction of complex stoichiometry and heterogeneity.
ISSN:0959-440X
1879-033X
1879-033X
DOI:10.1016/j.sbi.2024.102841