Fecal microbiota and volatile metabolome pattern alterations precede late-onset meningitis in preterm neonates

Fecal microbiota and volatile metabolome pattern alterations precede late-onset meningitis in preterm neonates

The fecal microbiota and metabolome are hypothesized to be altered before late-onset neonatal meningitis (LOM), in analogy to late-onset sepsis (LOS). The present study aimed to identify fecal microbiota composition and volatile metabolomics preceding LOM. Cases and gestational age-matched controls...

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Veröffentlicht in:The Journal of infectious diseases 2024-05
Hauptverfasser: Frerichs, Nina M, Deianova, Nancy, El Manouni El Hassani, Sofia, Acharjee, Animesh, Quraishi, Mohammed Nabil, de Boode, Willem P, Cossey, Veerle, Hulzebos, Christian V, van Kaam, Anton H, Kramer, Boris W, d'Haens, Esther, de Jonge, Wouter J, Vijlbrief, Daniel C, van Weissenbruch, Mirjam M, Daulton, Emma, Wicaksono, Alfian N, Covington, James A, Benninga, Marc A, de Boer, Nanne K H, van Goudoever, Johannes B, Niemarkt, Hendrik J, de Meij, Tim G J
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Sprache:eng
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Zusammenfassung:The fecal microbiota and metabolome are hypothesized to be altered before late-onset neonatal meningitis (LOM), in analogy to late-onset sepsis (LOS). The present study aimed to identify fecal microbiota composition and volatile metabolomics preceding LOM. Cases and gestational age-matched controls were selected from a prospective, longitudinal preterm cohort study (born
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jiae265