High-throughput enrichment of portal venous circulating tumor cells for highly sensitive diagnosis of CA19-9-negative pancreatic cancer patients using inertial microfluidics

The carbohydrate antigen 19-9 (CA19-9) is commonly used as a representative biomarker for pancreatic cancer (PC); however, it lacks sensitivity and specificity for early-stage PC diagnosis. Furthermore, some patients with PC are negative for CA19-9 (

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biosensors & bioelectronics 2024-09, Vol.259, p.116411, Article 116411
Hauptverfasser:	Zhu, Zhixian, Zhang, Yixuan, Zhang, Wenjun, Tang, Dezhi, Zhang, Song, Wang, Lei, Zou, Xiaoping, Ni, Zhonghua, Zhang, Shu, Lv, Ying, Xiang, Nan
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor - blood Biosensing Techniques - instrumentation CA-19-9 Antigen - blood Circulating tumor cell Female Humans Inertial microfluidics Liquid Biopsy - methods Male Microfluidic Analytical Techniques - instrumentation Microfluidics - methods Middle Aged Neoplastic Cells, Circulating - pathology Pancreatic cancer Pancreatic Neoplasms - blood Pancreatic Neoplasms - diagnosis Pancreatic Neoplasms - pathology Portal Vein Portal venous system Tumor-proximal liquid biopsy
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The carbohydrate antigen 19-9 (CA19-9) is commonly used as a representative biomarker for pancreatic cancer (PC); however, it lacks sensitivity and specificity for early-stage PC diagnosis. Furthermore, some patients with PC are negative for CA19-9 (
ISSN:	0956-5663 1873-4235 1873-4235
DOI:	10.1016/j.bios.2024.116411